PF-06455943 manufacturers
- PF-06455943
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- $1520.00
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2026-05-11
- CAS:1527474-15-2
- Purity:
- Supply Ability: 10g
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| | PF-06455943 Basic information |
| Product Name: | PF-06455943 | | Synonyms: | PF-06455943;Benzonitrile, 2-fluoro-3-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]- | | CAS: | 1527474-15-2 | | MF: | C17H14FN5O | | MW: | 323.33 | | EINECS: | | | Product Categories: | | | Mol File: | 1527474-15-2.mol |  |
| | PF-06455943 Chemical Properties |
| | PF-06455943 Usage And Synthesis |
| Uses | PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD)[1][2]. | | References | [1] Zhen Chen, et al. Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand. J Med Chem. 2022 Oct 18. DOI:10.1021/acs.jmedchem.2c00551
[2] Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. DOI:10.1021/jm5014055 |
| | PF-06455943 Preparation Products And Raw materials |
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