|
|
| | Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]- Basic information |
| | Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]- Chemical Properties |
| density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : ≥ 100 mg/mL (275.19 mM) | | form | Solid | | pka | 8.66±0.30(Predicted) | | color | Light yellow to yellow |
| | Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]- Usage And Synthesis |
| Uses | Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle[1]. | | References | [1] An W, et al. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents. Eur J Med Chem. 2016 Apr 13;112:367-372. DOI:10.1016/j.ejmech.2016.02.004 |
| | Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]- Preparation Products And Raw materials |
|