Benzamide, 3,4,5-trimethoxy-N-[1-[5-methyl-2-[(1-naphthalenylmethyl)thio][1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-3-piperidinyl]- manufacturers
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| | Benzamide, 3,4,5-trimethoxy-N-[1-[5-methyl-2-[(1-naphthalenylmethyl)thio][1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-3-piperidinyl]- Basic information |
| Product Name: | Benzamide, 3,4,5-trimethoxy-N-[1-[5-methyl-2-[(1-naphthalenylmethyl)thio][1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-3-piperidinyl]- | | Synonyms: | Benzamide, 3,4,5-trimethoxy-N-[1-[5-methyl-2-[(1-naphthalenylmethyl)thio][1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-3-piperidinyl]-;Antitumor agent-55 | | CAS: | 2522594-49-4 | | MF: | C32H34N6O4S | | MW: | 598.72 | | EINECS: | | | Product Categories: | | | Mol File: | 2522594-49-4.mol | ![Benzamide, 3,4,5-trimethoxy-N-[1-[5-methyl-2-[(1-naphthalenylmethyl)thio][1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-3-piperidinyl]- Structure](CAS/20210305/GIF/2522594-49-4.gif) |
| | Benzamide, 3,4,5-trimethoxy-N-[1-[5-methyl-2-[(1-naphthalenylmethyl)thio][1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-3-piperidinyl]- Chemical Properties |
| density | 1.34±0.1 g/cm3(Predicted) | | pka | 13.19±0.20(Predicted) |
| | Benzamide, 3,4,5-trimethoxy-N-[1-[5-methyl-2-[(1-naphthalenylmethyl)thio][1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-3-piperidinyl]- Usage And Synthesis |
| Uses | Antitumor agent-55 (compound 5q) is a potent antitumor agent. Antitumor agent-55 effectively inhibits PC3, with an IC50 of 0.91 μM. Antitumor agent-55 effectively inhibits the colony formation, suppresses the cell migration in PC3. Antitumor agent-55 induces G1/S phase arrest and apoptosis in PC3[1]. | | References | [1] Lu N, Huo JL, Wang S, Yuan XH, Liu HM. Drug repurposing: Discovery of troxipide analogs as potent antitumor agents. Eur J Med Chem. 2020;202:112471. DOI:10.1016/j.ejmech.2020.112471 |
| | Benzamide, 3,4,5-trimethoxy-N-[1-[5-methyl-2-[(1-naphthalenylmethyl)thio][1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-3-piperidinyl]- Preparation Products And Raw materials |
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