2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)-

Request For Quotation
2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)- manufacturers

  • BRG1-IN-1
  • BRG1-IN-1 pictures
  • $1980.00
  • 2026-05-11
  • CAS:2616813-99-9
  • Purity:
  • Supply Ability: 10g
2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)- Basic information
Product Name:2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)-
Synonyms:2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)-;BRG1-IN-1
CAS:2616813-99-9
MF:C20H19FN2O
MW:322.38
EINECS:
Product Categories:
Mol File:2616813-99-9.mol
2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)- Structure
2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)- Chemical Properties
Boiling point 478.0±45.0 °C(Predicted)
density 1.284±0.06 g/cm3(Predicted)
pka7.05±0.40(Predicted)
Safety Information
MSDS Information
2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)- Usage And Synthesis
UsesBRG1-IN-1 (Compound 11d) is a potent inhibitor of SMARCA4/BRG1. BRG1-IN-1 shows better efficacy than PFI-3 in sensitizing GBM cells to the antiproliferative and cell death inducing effects of Temozolomide in vitro. BRG1-IN-1 enhances the inhibitor effect of Temozolomide on the growth of subcutaneous GBM tumors[1].
References[1] He Y, et al. Novel structural-related analogs of PFI-3 (SRAPs) that target the BRG1 catalytic subunit of the SWI/SNF complex increase the activity of temozolomide in glioblastoma cells. Bioorg Med Chem. 2022 Jan 1;53:116533. DOI:10.1016/j.bmc.2021.116533
2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)- Preparation Products And Raw materials
Tag:2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)-(2616813-99-9) Related Product Information
PROTAC SMARCA2 degrader-2 Indolo[1,2-a]quinazolin-5(7H)-one, 4-chloro-7,7-dimethyl-10-(4-piperidinyl)- PROTAC SMARCA2 degrader-27 LW106 (2S,4R)-1-[(2R)-2-[3-[(1S)-2-[(3R)-3-[(6aS)-5,6,6a,7,9,10-Hexahydro-2-(2-hydroxyphenyl)-8H-pyrazino[1′,2′:4,5]pyrazino[2,3-c]pyridazin-8-yl]-1-pyrrolidinyl]-1-methylethoxy]-5-isoxazolyl]-3-methyl-1-oxobutyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-2-pyrrolidinecarboxamide 1H-Isoindole-1,3(2H)-dione, 5-[4-[[4-[[3-[3-[3-amino-6-(5-fluoro-2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]phenyl]methyl]-1-piperazinyl]carbonyl]-1-piperidinyl]-2-(2,6-dioxo-3-piperidinyl)-, 2,2,2-trifluoroacetate (1:2)