| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
- Ankaflavin
-
- $400.00
-
2026-07-27
- CAS:50980-32-0
- Purity:
- Supply Ability: 10g
- Ankaflavin
-
- $400.00
-
2026-07-27
- CAS:50980-32-0
- Purity:
- Supply Ability: 10g
- Ankaflavin
-
-
2025-07-19
- CAS:50980-32-0
- Purity:
- Supply Ability: 10g
|
| Product Name: | ANKAFLAVIN | | Synonyms: | ANKAFLAVIN;Anti-cancer Activity;2H-Furo[3,2-g][2]benzopyran-2,9(3H)-dione, 3a,4,8,9a-tetrahydro-9a-methyl-3-(1-oxooctyl)-6-(1E)-1-propen-1-yl-, (3S,3aR,9aR)-;Monascus flavan;Ankaflavin in Acetonitrile | | CAS: | 50980-32-0 | | MF: | C23H30O5 | | MW: | 386.48 | | EINECS: | | | Product Categories: | | | Mol File: | 50980-32-0.mol |  |
| | ANKAFLAVIN Chemical Properties |
| Boiling point | 590.7±50.0 °C(Predicted) | | density | 1.15±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | Soluble in DMSO | | form | Solid | | pka | 10.75±0.60(Predicted) | | color | Light yellow to yellow | | Major Application | (Pharmaceutical small molecule) | | InChIKey | AQTJNEHGKRUSLT-ODTNPMSZSA-N | | SMILES | C1(/C=C/C)OCC2C(=O)[C@]3(C)OC(=O)[C@H](C(=O)CCCCCCC)[C@@]3([H])CC=2C=1 |
| Storage Class | 11 - Combustible Solids |
| | ANKAFLAVIN Usage And Synthesis |
| Description | Ankaflavin (AK), isolated from Monascus-Fermented red rice, is a PPARγ agonist with anti-inlfammatory activity. Ankaflavin is an active compound having anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.
| | Anti-cancer Activity | Ankaflavin was found to be toxic to human cancer cell lines Hep G2 and A549 with a similar IC50 value of 15 μg/mL, while it posed no significant toxicity to normal MRC-5 and WI-38 cells at the same concentration.Ankaflavin exhibits selective cytotoxic effect and induces cell death on cancer cells.
| | Description | Ankaflavin is a microbial metabolite that has been found in M. ruber and has diverse biological activities.1,2,3 It induces cytotoxicity in HepG2 hepatic carcinoma and A549 lung cancer cells (IC50 = ~15 µg/ml for both).1 Ankaflavin (15 µg/ml) induces cell cycle arrest at the G0 phase in HepG2 cells. It reduces nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophages when used at concentrations of 5, 10, and 15 µg/ml.2 Ankaflavin (10 µM) increases lipolysis in 3T3-L1 adipocytes matured by isobutylmethylxanthine (IBMX; Item No. 13347), dexamethasone (Item No. 11015), and insulin.3 In vivo, ankaflavin (5 mg/kg per day) reduces blood glucose and serum insulin levels in mice fed a high-fat diet.WARNING This product is not for human or veterinary use. |
| | ANKAFLAVIN Preparation Products And Raw materials |
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