Methanone, (6-fluoro-1H-benzimidazol-2-yl)(7-fluoro-1H-indol-3-yl)-

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Email: marketing@targetmol.com

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Methanone, (6-fluoro-1H-benzimidazol-2-yl)(7-fluoro-1H-indol-3-yl)- Basic information
Product Name:Methanone, (6-fluoro-1H-benzimidazol-2-yl)(7-fluoro-1H-indol-3-yl)-
Synonyms:Methanone, (6-fluoro-1H-benzimidazol-2-yl)(7-fluoro-1H-indol-3-yl)-;PCSK9 modulator-3
CAS:2476490-18-1
MF:C16H9F2N3O
MW:297.26
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Mol File:2476490-18-1.mol
Methanone, (6-fluoro-1H-benzimidazol-2-yl)(7-fluoro-1H-indol-3-yl)- Structure
Methanone, (6-fluoro-1H-benzimidazol-2-yl)(7-fluoro-1H-indol-3-yl)- Chemical Properties
Boiling point 572.7±58.0 °C(Predicted)
density 1.531±0.06 g/cm3(Predicted)
pka8.78±0.10(Predicted)
Safety Information
MSDS Information
Methanone, (6-fluoro-1H-benzimidazol-2-yl)(7-fluoro-1H-indol-3-yl)- Usage And Synthesis
UsesPCSK9 modulator-3 (Compound 13) is a potent modulator of PCSK9 with an EC50 value of 2.46 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-3 has the potential for the research of hyperlipidemia[1].
References[1] Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678. DOI:10.1016/j.ejmech.2020.112678
Methanone, (6-fluoro-1H-benzimidazol-2-yl)(7-fluoro-1H-indol-3-yl)- Preparation Products And Raw materials
Tag:Methanone, (6-fluoro-1H-benzimidazol-2-yl)(7-fluoro-1H-indol-3-yl)-(2476490-18-1) Related Product Information
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