| Company Name: |
Cochemical Ltd. |
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029-86115547 17791676824 |
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sales@cochemical.com |
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| Product Name: | 1H-Benzimidazole,2-chloro-4-fluoro-(9CI) | | Synonyms: | 1H-Benzimidazole,2-chloro-4-fluoro-(9CI);2-Chloro-4-fluorobenzimidazole;1H-BENZIMIDAZOLE, 2-CHLORO-4-FLUORO-;2-Chloro-4-fluoro-1H-benzo[d]imidazole;2-chloro-4-fluoro-1H-1,3-benzodiazole;2-Chloro-7-fluoro-1H-benzo[d]imidazole;2-Chloro-4-fluoro-1H-benzimidazole;1H-Benzimidazole, 2-chloro-7-fluoro- | | CAS: | 256519-11-6 | | MF: | C7H4ClFN2 | | MW: | 170.57 | | EINECS: | | | Product Categories: | BENZIMIDAZOLE | | Mol File: | 256519-11-6.mol |  |
| | 1H-Benzimidazole,2-chloro-4-fluoro-(9CI) Chemical Properties |
| Boiling point | 332.9±34.0 °C(Predicted) | | density | 1.533±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 7.60±0.30(Predicted) | | form | crystalline powder | | color | Pale cream |
| | 1H-Benzimidazole,2-chloro-4-fluoro-(9CI) Usage And Synthesis |
| Uses | 2-Chloro-4-fluoro-(9CI)-1H-benzimidazole is a pharmaceutical intermediate that can be obtained by first preparing 4-fluoro-1H-benzimidazole-2(3H)-one from 3-fluorophenyl-1,2-diamine, followed by chlorination. It has been reported in the literature that it can be used to prepare ATR kinase inhibitors. | | Application | 2-Chloro-4-fluoro-(9CI)-1H-benzimidazole can be used to prepare 4-fluoro-N-methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonylimino)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazole-2-amine and 4-fluoro-N-methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((S)-S-methylsulfonylimino)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazole-2-amine. These two compounds have important applications in the treatment of proliferative diseases (such as cancer), particularly in diseases mediated by ataxia-telangiectasia mutations and RAD-3-related protein kinase inhibitors (commonly known as ATRs). |
| | 1H-Benzimidazole,2-chloro-4-fluoro-(9CI) Preparation Products And Raw materials |
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