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5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide

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5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide Basic information
Product Name:5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide
Synonyms:ITCL;N-(p-Chlorophenyl)-5-benzoylamino-3-methyl-4-isothiazolecarboxamide;T-15【ITCL】;5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide;4-Isothiazolecarboxamide, 5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-;5-benzamido-N-(4-chlorophenyl)-3-methyl-1,2-thiazole-4-carboxamide
CAS:51287-57-1
MF:C18H14ClN3O2S
MW:371.84
EINECS:
Product Categories:APIs
Mol File:51287-57-1.mol
5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide Structure
5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide Chemical Properties
Boiling point 360.0±42.0 °C(Predicted)
density 1.440±0.06 g/cm3(Predicted)
pka11.14±0.70(Predicted)
Safety Information
MSDS Information
5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide Usage And Synthesis
UsesDenotivir (Vratizolin) is an orally active antiviral agent for herpes simplex virus (HSV) and varicella-zoster virus (VZV). Denotivir inhibits the proliferation of various cancer cells, and exhibits anti-leukemic activity. Denotivir inhibits the generation of TNF-α, IL-1 and IL-6, exhibits immunosuppressive efficacy[1].
References[1] Machoń Z, et al., Immunotropic activity of vratizolin (ITCL, Denotivir). Pol J Pharmacol. 2001 Jul-Aug;53(4):377-83. PMID:11990084
5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide Preparation Products And Raw materials
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