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verrucarin J manufacturers
- Verrucarin J
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- $1980.00
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2026-05-11
- CAS:4643-58-7
- Purity:
- Supply Ability: 10g
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| | verrucarin J Basic information |
| Product Name: | verrucarin J | | Synonyms: | verrucarin J;Verrucrin J;Verrucarin A, 2',3'-didehydro-2'-deoxy-, (2'E)-;Verrucarin J
DISCONTINUED | | CAS: | 4643-58-7 | | MF: | C27H32O8 | | MW: | 484.54 | | EINECS: | | | Product Categories: | | | Mol File: | 4643-58-7.mol |  |
| | verrucarin J Chemical Properties |
| alpha | D19 +54° (benzene); D22 +20 ± 2° (c = 1.011 in chloroform) | | Boiling point | 735.4±60.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | solubility | Dichloromethane: Soluble
DMSO: Soluble
Ethanol: Soluble
Methanol: Soluble | | form | powder | | color | White |
| RIDADR | 3172 | | HazardClass | 6.1(a) | | PackingGroup | I | | HS Code | 2941900000 |
| | verrucarin J Usage And Synthesis |
| Uses | Verrucarin J can be used in biological study of characteristics of toxigenic properties of Myrothecium cinctum and Myrothecium commune. | | Definition | ChEBI: Verrucarin j is a trichothecene. | | in vivo | Verrucarin J (0.5mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model[2].
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis[5]. | Animal Model: | 6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts[2] | | Dosage: | 0.5mg/kg body weight | | Administration: | i.p. for 4 weeks | | Result: | Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors. |
| Animal Model: | Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts[5] | | Dosage: | 0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate) | | Administration: | i.p. for three weeks after 10 days of injection of A2780 cells | | Result: | Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg.
Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg.
Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg.
In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments.
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| | References | [1] MINH VAN NGUYEN. Curvicollide D, a new modified γ-lactone from the culture broth of Albifimbria verrucaria and its antifungal activity against plant pathogenic fungi[J]. Journal of Antibiotics, 2022, 75 9: 514-518. DOI: 10.1038/s41429-022-00541-7
[2] KAREN UDOH. Targeting of Lung Cancer Stem Cell Self-Renewal Pathway by a Small Molecule Verrucarin J.[J]. Stem Cell Reviews and Reports, 2019, 15 4: 601-611. DOI: 10.1007/s12015-019-09874-7
[3] DEEKSHA PAL. Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer.[J]. ACS Biomaterials Science & Engineering, 2018: 798. DOI: 10.1038/s41419-018-0810-8 |
| | verrucarin J Preparation Products And Raw materials |
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