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| | leucettamine A Basic information |
| Product Name: | leucettamine A | | Synonyms: | leucettamine A;5,8,11,14,17,20-Triacontahexaene-3,28-diol, 2,29-diamino-, (2R,3S,5Z,8Z,11Z,14Z,17Z,20Z,28S,29R)- | | CAS: | 151124-32-2 | | MF: | C30H52N2O2 | | MW: | 472.75 | | EINECS: | | | Product Categories: | | | Mol File: | 151124-32-2.mol |  |
| | leucettamine A Chemical Properties |
| Boiling point | 606.8±55.0 °C(Predicted) | | density | 0.966±0.06 g/cm3(Predicted) | | pka | 12.56±0.45(Predicted) |
| | leucettamine A Usage And Synthesis |
| Uses | Leucettamol A is an inhibitor of Ubc13 (ubiquitin E2 enzyme)-Uev1A interaction, with an IC50 of 50 μg/mL. Leucettamol A can potentially activate the expression of cancer suppressor p53 and is a precursor of anticancer agents. Leucettamol A can be isolated from a marine sponge, Leucetta aff. Microrhaphis[1][2]. | | References | [1] Sachiko Tsukamoto, et al. Leucettamol A: a new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. Microrhaphis. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6319-20. DOI:10.1016/j.bmcl.2008.10.110
[2] Kimberli M Helms, et al. Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K. Nat Prod Commun. 2011 Oct;6(10):1411-6. PMID:22164771 |
| | leucettamine A Preparation Products And Raw materials |
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