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| | Tauro-ω-muricholic Acid (sodium salt) Basic information |
| | Tauro-ω-muricholic Acid (sodium salt) Chemical Properties |
| storage temp. | -20°C | | solubility | DMF: 10 mg/ml
DMSO: 10 mg/ml
DMSO: PBS (pH 7.2) (1:4): 0.2 mg/ml
Ethanol: 1 mg/ml | | form | Solid | | color | White to off-white |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Tauro-ω-muricholic Acid (sodium salt) Usage And Synthesis |
| Uses | Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies[1][2] | | in vivo | Sprague–Dawley rats are fed a standard diet with 1 week, and then randomly assigned to the two groups. The control group received a normal diet (10 kcal%), while the NAFLD group is fed a high-fat diet (60 kcal%; 18 weeks)[1].
10 BAs from the NAFLD group are significantly decreased in the liver, including 4 tauro-conjugated BA species including taurolithocholic acid (TLCA), THDCA, taurodeoxycholic acid (TDCA) and tauro ω-muricholic acid (TωMCA). Furthermore, βDCA, HDCA, 6-ketoLCA, 23-nordeoxycholic acid (NorDCA), LCA and 3β-chenodeoxycholic acid (βCDCA) shows lower levels in the NAFLD group[2].
| | References | [1] Zhrer E, et al. Neonatalsepsisleadstoearlyriseofrareserumbileacidtauro-omega-muricholicacid(TOMCA).Pediatr Res.2018 Jul;84(1):66-70. DOI:10.1038/s41390-018-0007-y
[2] Tang Y, et al. Turnoverofbileacidsinliver,serumandcaecalcontentbyhigh-fatdietfeedingaffectshepaticsteatosisinrats. Biochim Biophys Acta Mol Cell Biol Lipids.2019 Oct;1864(10):1293-1304 DOI:10.1016/j.bbalip.2019.05.016
[3] YOUCAI ZHANG Curtis D K. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice.[J]. Journal of Lipid Research, 2010, 51 11: 3230-3242. DOI: 10.1194/jlr.m007641 |
| | Tauro-ω-muricholic Acid (sodium salt) Preparation Products And Raw materials |
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