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Product Name:Tauro-α-muricholic acid sodium salt
CAS:2260905-08-4
Purity:95% Package:1G;10G;100G
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Product Name:Tauro-α-muricholic Acid Sodium Salt
CAS:2260905-08-4
Purity:98% Package:1mg Remarks:B45091
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Product Name:Tauro-α-muricholic Acid (sodium salt)
CAS:2260905-08-4
Purity:>98% Package:1mg;10mg;50mg;100mg;
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Product Name:Tauro-α-muricholic Acid sodium salt
CAS:2260905-08-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Tauro-α-muricholic acid sodium salt manufacturers
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| | Tauro-α-muricholic acid sodium salt Basic information |
| Product Name: | Tauro-α-muricholic acid sodium salt | | Synonyms: | 2-[[(3α,5β,6β,7α)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonicacid,monosodiumsalt;Tauro-α-Muricholic Acid-[d5] Sodium Salt;Tauro-α-muricholic acid sodium;D4-Tauro-α-muricholic Acid Sodium Salt;Tauro-α-muricholic Acid (sodium salt) (Standard) | | CAS: | 2260905-08-4 | | MF: | C26H46NNaO7S | | MW: | 539.7 | | EINECS: | | | Product Categories: | | | Mol File: | 2260905-08-4.mol |  |
| | Tauro-α-muricholic acid sodium salt Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 10 mg/mL; DMSO: 10 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 1 mg/mL | | form | A crystalline solid | | color | White to off-white |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Tauro-α-muricholic acid sodium salt Usage And Synthesis |
| Description | Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid .1 TαMCA is common in rodents but has also been found in small amounts in human serum.2 | | Uses | Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal[1][2]. | | IC 50 | Microbial Metabolite | | References | 1. Sayin, S.I., Wahlstrm, A., Felin, J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist Cell Metab. 17(2),225-235(2013).
2. García-Caaveras, J.C., Donato, M.T., Castell, J.V., et al. Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method J. Lipid Res. 53(10),2231-2241(2012). |
| | Tauro-α-muricholic acid sodium salt Preparation Products And Raw materials |
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