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| | negamycin Basic information |
| Product Name: | negamycin | | Synonyms: | negamycin;(3R,5R)-3,6-Diamino-5-hydroxyhexanoic acid 2-(carboxymethyl)-2-methyl hydrazide;(3R,5R)-3,6-Diamino-5-hydroxyhexanoic acid-N'-methyl-N'-(2-oxo-2-hydroxyethyl) hydrazide;L-threo-Hexonic acid, 3,6-diamino-2,3,4,6-tetradeoxy-, 2-(carboxymethyl)-2-methylhydrazide | | CAS: | 33404-78-3 | | MF: | C9H20N4O4 | | MW: | 248.28 | | EINECS: | | | Product Categories: | | | Mol File: | 33404-78-3.mol |  |
| | negamycin Chemical Properties |
| Melting point | 110-120° (dec) | | alpha | D29 +2.5° (c = 2) | | density | 1.303±0.06 g/cm3(Predicted) | | pka | pKa values after treatment with HCl-methanol: 3.55, 8.10, 9.75(at 25℃) |
| Toxicity | LD50 i.v. in mice: 400-500 mg/kg (Hameda) |
| | negamycin Usage And Synthesis |
| Uses | Negamycin is a compound with antibacterial activity that inhibits protein synthesis by binding to the head domain of the bacterial ribosomal small subunit, leading to cell death, and also promotes misreading of near-cognate codons. | | References | [1] Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome DOI:10.1073/pnas.1414401111 |
| | negamycin Preparation Products And Raw materials |
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