| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:antibiotic 1233A
CAS:29066-42-0
Purity:科研试剂 Package:1mg Remarks:T68906
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antibiotic 1233A manufacturers
- Hymeglusin
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- $765.00 / 1mg
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2025-09-11
- CAS:29066-42-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | antibiotic 1233A Basic information |
| Product Name: | antibiotic 1233A | | Synonyms: | 1233A;Antibiotic F-244;F-244;L-659699;(R,R)-HyMeglusin;(2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-2,4-undecadienoic acid;Hymeglusin;(2E, 4E, 7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxooxetan-2-yl]-3,5,7-trimethylundeca-2,4-dienoic acid | | CAS: | 29066-42-0 | | MF: | C18H28O5 | | MW: | 324.41 | | EINECS: | | | Product Categories: | | | Mol File: | 29066-42-0.mol |  |
| | antibiotic 1233A Chemical Properties |
| Boiling point | 516.6±15.0 °C(Predicted) | | density | 1.101±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble | | form | powder | | pka | 4.98±0.33(Predicted) | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| WGK Germany | 3 | | RTECS | YQ1170000 |
| | antibiotic 1233A Usage And Synthesis |
| Description | Hymeglusin (29066-42-0) is an inhibitor of eukaryotic mevalonate biosynthesis via inhibition of HMG-CoA synthase, IC50=0.12 μM.1 Acts via covalent modification of the active site Cys129.1,2 Inhibits cholesterol biosynthesis in rats (45% at 25 mg/Kg).1 Also inhibits bacterial HMG-CoA synthase.3 Inhibits dengue virus replication.4 | | Uses | Hymeglusin is an irreversible HMG-CoA synthase inhibitor. | | Definition | ChEBI: Hymeglusin is a long-chain fatty acid. | | in vivo | At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45 %[2]. | | storage | +4°C | | References | [1] M D GREENSPAN. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 21: 7488-7492. DOI:10.1073/pnas.84.21.7488
[2] HIROSHI TOMODA. Binding site for fungal β-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2004, 1636 1: Pages 22-28. DOI:10.1016/j.bbalip.2003.11.005
[3] D. ANDREW SKAFF. Biochemical and Structural Basis for Inhibition of Enterococcus faecalis Hydroxymethylglutaryl-CoA Synthase, mvaS, by Hymeglusin[J]. Biochemistry Biochemistry, 2012, 51 23: 4713-4722. DOI:10.1021/bi300037k
[4] CHRISTOPHER ROTHWELL . Cholesterol biosynthesis modulation regulates dengue viral replication[J]. Virology, 2009, 389 1: Pages 8-19. DOI:10.1016/j.virol.2009.03.025 |
| | antibiotic 1233A Preparation Products And Raw materials |
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