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| | jolkinolide A Basic information |
| Product Name: | jolkinolide A | | Synonyms: | jolkinolide A;(4aR,6aS,7aβ)-2,3,4,4aα,5,6,11aα,11b-Octahydro-4,4,8,11bβ-tetramethyl-1H-oxireno[1,10a]phenanthro[3,2-b]furan-9(7aH)-one;(5β,9β,10α)-8β,14β:12,16-Diepoxyabieta-11,13(15)-dien-16-one;1H-Oxireno[1,10a]phenanthro[3,2-b]furan-9(7aH)-one, 2,3,4,4a,5,6,11a,11b-octahydro-4,4,8,11b-tetramethyl-, (4aR,6aS,7aR,11aS,11bR)- | | CAS: | 37905-07-0 | | MF: | C20H26O3 | | MW: | 314.42 | | EINECS: | | | Product Categories: | | | Mol File: | 37905-07-0.mol |  |
| | jolkinolide A Chemical Properties |
| Boiling point | 479.5±45.0 °C(Predicted) | | density | 1.19±0.1 g/cm3(Predicted) | | InChI | InChI=1S/C20H26O3/c1-11-15-12(22-17(11)21)10-14-19(4)8-5-7-18(2,3)13(19)6-9-20(14)16(15)23-20/h10,13-14,16H,5-9H2,1-4H3/t13-,14+,16-,19-,20+/m1/s1 | | InChIKey | OYXDHOVYZKWSRM-PHJMNMFVSA-N |
| | jolkinolide A Usage And Synthesis |
| Uses | Jolkinolide A can be used as a bone marrow mesenchymal stem cell osteogenic differentiation accelerator. It can be developed using matrix solid-phase dispersion coupled with high-performance liquid chromatography. | | Definition | ChEBI: A natural product found in Euphorbia fischeriana. | | in vivo | Jolkinolide A (40 mg/kg; i.p.; once every 3 days, for 2 months) inhibits the expression of the VEGF protein in A549 cell xenograft tumor model in mouse[1]. | Animal Model: | Female BALB/c nude mice (4-5 weeks old) injected with A549 cells[1] | | Dosage: | 40 mg/kg | | Administration: | Intraperitoneal injection; once every 3 days for 2 months | | Result: | Significantly inhibited the expression of VEGF protein on the first, 10th, 30th, 45th, and 60th day of administration. |
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| | jolkinolide A Preparation Products And Raw materials |
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