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- Ansatrienin B
-
- $883.00
-
2026-07-16
- CAS:82189-04-6
- Purity:
- Supply Ability: 10g
- Ansatrienin B
-
- $1280.00
-
2025-12-22
- CAS:82189-04-6
- Purity:
- Supply Ability: 10g
|
| | mycotrienin II Basic information |
| Product Name: | mycotrienin II | | Synonyms: | mycotrienin II;20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A 11-[(R)-2-(cyclohexylcarbonylamino)propanoate];T 23II, Mycotrienin II, T 23II;D-Alanine, N-(cyclohexylcarbonyl)-, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester | | CAS: | 82189-04-6 | | MF: | C36H50N2O8 | | MW: | 638.79 | | EINECS: | | | Product Categories: | | | Mol File: | 82189-04-6.mol |  |
| | mycotrienin II Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble in DMSO, DMF, Ethanol or Methanol | | form | solid | | color | Pale-yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol, or methanol may be stored at -20°C for up to 3 months. |
| | mycotrienin II Usage And Synthesis |
| Description | Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1 expression induced by pro-inflammatory cytokines.4 | | Uses | Ansatrienin B, also known as Mycotrienin II and Antibiotic T 23II, was isolated from a Streptomyces sp.. Closely related to the cytotrienins and trienomycins, it displays potent activity against tumour cell lines and inhibits osteoclastic bone resorption. Ansatrienin B also significantly potentiates the action of several clinical anti-cancer agents. | | in vivo | Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice[2]. | | References | [1] M SUGITA. Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II.[J]. Journal of Antibiotics, 1982, 35 11: 1467-1473. DOI:10.7164/antibiotics.35.1467
[2] D FEUERBACH. Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption.[J]. The Journal of Biological Chemistry, 1995, 270 43: 25949-25955. DOI:10.1074/jbc.270.43.25949
[3] YURIKO YAMADA. Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines[J]. Journal of Antibiotics, 2011, 64 5: 361-366. DOI:10.1038/ja.2011.23 |
| | mycotrienin II Preparation Products And Raw materials |
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