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| | kobusine Basic information |
| Product Name: | kobusine | | Synonyms: | kobusine;Hetisan-11β,15β-diol;Hetisan-11,15-diol, (11β,15β)- | | CAS: | 27530-78-5 | | MF: | C20H27NO2 | | MW: | 313.43 | | EINECS: | | | Product Categories: | | | Mol File: | 27530-78-5.mol |  |
| | kobusine Chemical Properties |
| Melting point | 267-267.5°C | | density | 1.372±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 14.294±0.60(predicted) |
| | kobusine Usage And Synthesis |
| Description | Obtained by Suginome and Shimanouti from the precipitation liquors of crude
jesaconitine from Aconitum sachalinense, Fr. Schmidt, this alkaloid crystallizes
from Me2CO in the rhombic-bisphenoidal system and has (a:b:c = 1.0736: I:
0.9811). It furnishes crystalline salts: the hydrobromide crystallizes as the mono_x0002_hydrate, m.p. 288°C (dec.); [α]22D + 40.68° (H20); hydrochloride (1.5 H20) has
m.p. 300°C (dec.);[α]21Dl + 41.4° (H20); perchlorate, m.p. 185-7°C (dec.)
although a value of 220°C has also been recorded for this salt; platinichloride,
m.p. 262°C (dec.); picrate, m.p. 282-4°C (dec.) and methiodide, m.p. 287°C
(dec.). The alkaloid forms a diacetyl derivative, m.p. 139-140°C and catalytic
reduction followed by acetylation yields a triacetyltetrahydrokobusine, m.p.
183-4°C (dec.). The alkaloid cannot be hydrolyzed and is non-toxic. | | References | Suginome, Shimanouti., Annalen, 545, 220 (1940)
Okamoto., Chern. Pharm. Bull. (Tokyo), 7,44 (1959)
Natsume., ibid, 7,539 (1959) |
| | kobusine Preparation Products And Raw materials |
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