H-L-Lys(4-N3-Z)-OH hydrochloride

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H-L-Lys(4-N3-Z)-OH hydrochloride Basic information
Product Name:H-L-Lys(4-N3-Z)-OH hydrochloride
Synonyms:H-L-Lys(4-N3-Z)-OH hydrochloride;L-Lysine, N6-[[(4-azidophenyl)methoxy]carbonyl]-, hydrochloride (1:1);H-L-Lys(4-N3-Z)-OH.HCl
CAS:2084913-49-3
MF:C14H19N5O4.ClH
MW:357.79
EINECS:
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Mol File:2084913-49-3.mol
H-L-Lys(4-N3-Z)-OH hydrochloride Structure
H-L-Lys(4-N3-Z)-OH hydrochloride Chemical Properties
form Solid
color White to light yellow
Safety Information
MSDS Information
H-L-Lys(4-N3-Z)-OH hydrochloride Usage And Synthesis
UsesH-L-Lys(4-N3-Z)-OH hydrochloride is a click chemistry reagent containing an azide group. H-L-Lys(4-N3-Z)-OH hydrochloride contains a lysine-modified azide moiety and as a bioorthogonal ligation handle. H-L-Lys(4-N3-Z)-OH hydrochloride is an infrared probe and a photo-affinity reagent[1][2]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
References[1] Ge Y, et, al. A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells. Chem Sci. 2016 Dec 1;7(12):7055-7060. DOI:10.1039/c6sc02615j
[2] Wesalo JS, et, al. Phosphine-Activated Lysine Analogues for Fast Chemical Control of Protein Subcellular Localization and Protein SUMOylation. Chembiochem. 2020 Jan 15;21(1-2):141-148. DOI:10.1002/cbic.201900464
H-L-Lys(4-N3-Z)-OH hydrochloride Preparation Products And Raw materials
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