NAMPT activator-6

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NAMPT activator-6 Suppliers list
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ：65489617 13301690235
Email: Sales@ATKchemical.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
NAMPT activator-6 Basic information
Product Name:NAMPT activator-6
Synonyms:NAMPT activator-6;Urea, N-[4-(1-piperazinylsulfonyl)phenyl]-N′-(4-pyridinylmethyl)-
CAS:2237267-86-4
MF:C17H21N5O3S
MW:375.45
EINECS:
Product Categories:
Mol File:2237267-86-4.mol
NAMPT activator-6 Structure
NAMPT activator-6 Chemical Properties
density 1.357±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka12.27±0.46(predicted)
Safety Information
MSDS Information
NAMPT activator-6 Usage And Synthesis
UsesNAMPT activator-6 is a NAMPT activator, a regulatory molecule for the optical control system of NAMPT and NAD+. NAMPT activator-6 can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) to achieve up-down reversible regulation of NAMPT and NAD+ in a light-dependent manner and reduce the toxicity associated with inhibitor-based PS-PROTACs. PS-PROTAC can be used to achieve antitumor activity, NAMPT, and NAD+ modulation in vivo via optical manipulation[1].
References[1] Cheng J, et al. Photoswitchable PROTACs for Reversible and Spatiotemporal Regulation of NAMPT and NAD. Angew Chem Int Ed Engl. 2024 Mar 18;63(12):e202315997. DOI:10.1002/anie.202315997
NAMPT activator-6 Preparation Products And Raw materials
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