| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- GNE-617
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- $77.00
-
2026-07-14
- CAS:1362154-70-8
- Purity: 99.71%
- Supply Ability: 10g
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| | GNE 617 Basic information |
| Product Name: | GNE 617 | | Synonyms: | GNE 617;GNE617;N-[[4-[(3,5-Difluorophenyl)sulfonyl]phenyl]methyl]imidazo[1,2-a]pyridine-6-carboxamide;N-(4-((3,5-difluorophenyl)sulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide;CS-1587;GNE617;GNE 617;Imidazo[1,2-a]pyridine-6-carboxamide, N-[[4-[(3,5-difluorophenyl)sulfonyl]phenyl]methyl]-;GNE-617 (CAS 1362154-70-8) | | CAS: | 1362154-70-8 | | MF: | C21H15F2N3O3S | | MW: | 427.42 | | EINECS: | | | Product Categories: | API | | Mol File: | 1362154-70-8.mol |  |
| | GNE 617 Chemical Properties |
| density | 1.42±0.1 g/cm3(Predicted) | | solubility | DMF:20.0(Max Conc. mg/mL);46.79(Max Conc. mM)
DMSO:78.67(Max Conc. mg/mL);26.22(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.47(Max Conc. mM) | | pka | 11.69±0.46(Predicted) | | form | Powder | | color | White to off-white |
| | GNE 617 Usage And Synthesis |
| Uses | GNE-617 is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer. | | in vivo | In rats, GNE-617 (administered QD) and GNE-875 (administered BID) are associated with more severe retinal toxicity at similar exposures and dosing duration compared with GMX-1778 (administered BID). The mouse efficacy studies using GNE-617, GNE-618, and GMX-1778 are designed to assess efficacy and opportunistically used to assess retinal toxicity in mice. NAMPTi retinal toxicity is observed with GNE-617 and GMX-1778; however, the different study durations between GNE-617 and GMX-1778 do not allow for direct comparison of retinal toxicity[2]. | | References | [1] Shames DS, et al. Loss of NAPRT1 Expression by Tumor-specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors. Clin Cancer Res. 2013 Dec 15;19(24):6912-23. DOI:10.1158/1078-0432.CCR-13-1186
[2] Zabka TS, et al. Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase. Toxicol Sci. 2015 Mar;144(1):163-72. DOI:10.1093/toxsci/kfu268 |
| | GNE 617 Preparation Products And Raw materials |
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