|
|
| | VNPP433-3β Basic information |
| Product Name: | VNPP433-3β | | Synonyms: | VNPP433-3β;1H-Benzimidazole, 1-[(3β)-3-(1H-imidazol-1-yl)androsta-5,16-dien-17-yl]- | | CAS: | 1630820-51-7 | | MF: | C29H34N4 | | MW: | 438.61 | | EINECS: | | | Product Categories: | | | Mol File: | 1630820-51-7.mol |  |
| | VNPP433-3β Chemical Properties |
| Melting point | 180-184 °C | | Boiling point | 645.531±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.292±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 6.883±0.10(predicted) | | form | Solid | | color | Light yellow to yellow |
| | VNPP433-3β Usage And Synthesis |
| Uses | VNPP433-3β is a molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. VNPP433-3β inhibits proliferation of cancer cell LNCaP, C4-2B and CWR22Rv1 with GI50 of 0.2, 0.3 and 0.31 μM. VNPP433-3β exhibits good pharmacokinetic characters in CD-1 mouse and inhibits tumor growth in the CWR22Rv1 xenograft mouse model[1]. | | References | [1] Thankan RS, et al., Salinization Dramatically Enhance the Anti-Prostate Cancer Efficacies of AR/AR-V7 and Mnk1/2 Molecular Glue Degraders, Galeterone and VNPP433-3β Which Outperform Docetaxel and Enzalutamide in CRPC CWR22Rv1 Xenograft Mouse Model. Bioorg Chem. 2023 Oct;139:106700. DOI:10.1016/j.bioorg.2023.106700 |
| | VNPP433-3β Preparation Products And Raw materials |
|