| 中文名称 | 10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)- |
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| 中文同义词 | |
| 英文名称 | 10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)- |
| 英文同义词 | 10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)- |
| CAS号 | 2697112-33-5 |
| 分子式 | C40H43ClFN5O5S |
| 分子量 | 760.32 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2697112-33-5.mol |
| 结构式 | ![10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)- 结构式](CAS/20240320/GIF/2697112-33-5.gif) |
10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)- 性质
| 沸点 | 958.3±65.0 °C(predicted) |
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| 密度 | 1.37±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) |
10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)- 用途与合成方法
JNJ-4355 是一种高效的 MCL-1 (髓细胞白血病 -1) 抑制剂，其 KI 为 18 pM。JNJ-4355 具有抗肿瘤活性。