10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)-

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10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)- Basic information
Product Name:10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)-
Synonyms:10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)-
CAS:2697112-33-5
MF:C40H43ClFN5O5S
MW:760.32
EINECS:
Product Categories:
Mol File:2697112-33-5.mol
10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)- Structure
10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)- Chemical Properties
Boiling point 958.3±65.0 °C(predicted)
density 1.37±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
Safety Information
MSDS Information
10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)- Usage And Synthesis
UsesJNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity[1][2].
in vivo

JNJ-4355 (IV , single) shows complete tumor regression in a mouse MOLP8 (multiple myeloma) xenograft[2].

IC 50Mcl-1: 18 pM (Ki)
References[1] Matthieu Jouffroy, et al. Synthesis of Atropisomeric Biaryls via Chiral Suzuki–Miyaura/Enzymatic Kinetic Resolution. ACS Catal. 2022, 12, 8380–8385.
[2] Frederik J. Rombouts, et al. Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355. Cancer Res (2022) 82 (12_Supplement): 2133.
10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)- Preparation Products And Raw materials
Tag:10H,18H-4,1-([4,3]-endo-Pyrazolomethanothiomethano[3,5]-endo-pyrazoloethano[3,1]naphthalenoxypropano)-1H-indole-2-carboxylic acid, 5-chloro-28-fluoro-10-[2-(2-methoxyethoxy)ethyl]-3,12,18-trimethyl-, (4S)-(2697112-33-5) Related Product Information
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