| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:SJ-C1044
CAS:2121503-76-0
Package:50mg/RMB 15600
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| | SJ-C1044 Basic information |
| Product Name: | SJ-C1044 | | Synonyms: | SJ-C1044;Benzamide, N-[2-fluoro-5-[[3-(9H-purin-6-yl)-2-pyridinyl]amino]phenyl]-3,5-bis(trifluoromethyl)- | | CAS: | 2121503-76-0 | | MF: | C25H14F7N7O | | MW: | 561.41 | | EINECS: | | | Product Categories: | | | Mol File: | 2121503-76-0.mol |  |
| | SJ-C1044 Chemical Properties |
| Boiling point | 610.422±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.576±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 8.419±0.10(predicted) |
| | SJ-C1044 Usage And Synthesis |
| Uses | SJ-C1044 is an orally available pan-RAF inhibitor with immunomodulatory and anti-tumor activities. SJ-C1044 inhibits wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 inhibits tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. In addition, SJ-C1044 also has a certain inhibitory effect on VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM, respectively. SJ-C1044 improves the tumor immune microenvironment by inhibiting angiogenesis and regulating macrophage function. SJ-C1044 can be used in the study of colorectal cancer[1]. | | IC 50 | VEGFR2: 100 nM (IC50); BRAFWT: 331 nM (IC50); BRafV600E: 187 nM (IC50); CRAF: 257 nM (IC50); Tie2: 23 nM (IC50); CSF1R: 235 nM (IC50) | | References | [1] Sungpyo Hong, et al. "Targeting RAF isoforms and tumor microenvironments in RAS or BRAF mutant colorectal cancers with SJ-C1044 for anti-tumor activity." Current Issues in Molecular Biology 45.7 (2023): 5865-5878. DOI:10.3390/cimb45070371 |
| | SJ-C1044 Preparation Products And Raw materials |
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