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| | Tcy-NH2 Basic information |
| Product Name: | Tcy-NH2 | | Synonyms: | TRANS-CINNAMOYL-TYR-PRO-GLY-LYS-PHE-NH2;TRANS-CINNAMOYL-YPGKF-AMIDE;M.W. 739.87 C40H49N7O7;trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-amide trifluoroacetate salt;trans-Cinnamoyl-YPGKF-NH2, tcY-NH2;trans-Cinnamoyl-YPGKF-NH2;L-Phenylalaninamide, N-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-L-tyrosyl-L-prolylglycyl-L-lysyl-;Protease-Activated Receptor-4, PAR-4 Antagonist, amide - 1 mg | | CAS: | 327177-34-4 | | MF: | C40H49N7O7 | | MW: | 739.86 | | EINECS: | | | Product Categories: | Proteinase-activated receptor (PAR) | | Mol File: | 327177-34-4.mol |  |
| | Tcy-NH2 Chemical Properties |
| storage temp. | −20°C | | form | Powder | | Water Solubility | Soluble to 1 mg/ml in water |
| | Tcy-NH2 Usage And Synthesis |
| Uses | tcY-NH2 does not cause aggregation but blocks aggregation caused by receptor-activating peptide analogs (GY-NH2, AY-NH2), and thrombin without affecting ADP-mediated aggregation. | | in vivo | tcY-NH2 (tail vein injection, 0.6 mg/kg for a single dose) alleviates liver injury in Brain death (BD) rat model, indicated by lower serum ALT/AST levels and better histomorphology[3].
tcY-NH2 (intraperitoneal injection, 0.6 mg/kg for a single dose) increases posttraumatic activation of CD4+ Tregs within the draining lymph nodes in burn injury mice model [4].
tcY-NH2 (intrapleural injection, 40 ng/kg for a single dose) inhibits neutrophil recruitment in experimental inflammation in mice[6].
| Animal Model: | Brain death (BD) rat model[3] | | Dosage: | 0.6 mg/kg for a single dose | | Administration: | Tail vein injection for a single dose | | Result: | Reduced blood platelet activation and hepatic platelet accumulation.
Attenuated the inflammatory response and apoptosis in the livers.
Inhibited the activation of NF-κB and MAPK pathways induced by Brain death (BD).
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| Animal Model: | Burn injury model of C57BL/6 N mice[4] | | Dosage: | 0.6 mg/kg for a single dose | | Administration: | Intraperitoneal injection | | Result: | Increased expression and phosphorylation of PKC-θ in the presence of platelets, without affecting early posttraumatic hemostasis.
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| Animal Model: | BALB/c mice[6] | | Dosage: | 40 ng/kg for a single dose | | Administration: | Intrapleural injection | | Result: | Abolished the number of rolling and adhering neutrophils on the vessel wall.
Inhibited CXCL8- and Cg-induced neutrophil migration into the pleural cavity of mice.
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| | IC 50 | PAR4 | | storage | Store at -20°C |
| | Tcy-NH2 Preparation Products And Raw materials |
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