| Company Name: |
Enzo Biochem Inc |
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Email: |
Enzoname@qq.com |
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| | Peroxiredoxin-2, human, recombinant Basic information |
| | Peroxiredoxin-2, human, recombinant Chemical Properties |
| | Peroxiredoxin-2, human, recombinant Usage And Synthesis |
| Description | Peroxiredoxin-2 (Prx2) is a typical 2-Cys-containing Prx that is involved in the maintenance of cellular thiol redox homeostasis.1 It exists as a homodimer and is composed of a thioredoxin fold-containing catalytic domain, which contains peroxidatic and resolving cysteines (Cp and Cr, respectively), and a C-terminal arm.2 Prx2 is ubiquitously expressed and localizes to the cytosol, nucleus, mitochondria, and peroxisomes.3,1 During the catalytic cycle, hydrogen peroxide oxidizes Cp to form a sulfenic acid intermediate (C-SOH), which reacts with the Cr of the opposite subunit to form a disulfide bond that is subsequently restored to a reduced state by thioredoxin (Trx) or other thiols.1,2 Prx2 primarily acts on hydrogen peroxide but also reduces other peroxides, including lipid hydroperoxides, protein peroxides, peroxynitrite, and peroxymonocarbonate and plays an important role in resolution of oxidized hemoglobin and erythrocyte membranes.2 Cerebrospinal fluid levels of Prx2 are increased in patients with subarachnoid hemorrhage, and substantia nigra levels of Prx2 are increased in patients with Parkinson’s disease.1 Prx2 acts as a tumor-suppressor or -promotor in a context-dependent manner in various cancers. Cayman’s Peroxiredoxin-2 (human, recombinant) protein can be used for enzyme activity assays. This protein consists of 217 amino acids and has a calculated molecular weight of 24 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 27 kDa.WARNING This product is not for human or veterinary use. |
| | Peroxiredoxin-2, human, recombinant Preparation Products And Raw materials |
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