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| | GBA3 (human, recombinant) Basic information |
| | GBA3 (human, recombinant) Chemical Properties |
| | GBA3 (human, recombinant) Usage And Synthesis |
| Description | Cytosolic β-glucosidase (GBA3) is a neutral β-glucocerebrosidase.1,2 It is composed of a single glycoside hydrolase domain and hydrolyzes glucosyl- and galactosylceramides. GBA3 is expressed in the liver, small intestine, colon, spleen, and kidneys.3 In vitro, knockdown of GBA3 inhibits mitotic arrest and promotes resistance to paclitaxel (Item No. 10461) in colon cancer cells.4 Tumor levels of GBA3 are lower in patients with hepatocellular carcinoma and decreased expression is associated with poor prognosis.5 Unlike GBA1, polymorphisms in GBA3 are not associated with Gaucher disease, a lysosomal storage disorder.6 Cayman’s GBA3 (human, recombinant) protein can be used for enzyme activity assays. This protein consists of 480 amino acids and has a calculated molecular weight of 55 kDa.WARNING This product is not for human or veterinary use. |
| | GBA3 (human, recombinant) Preparation Products And Raw materials |
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