SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain L452R, T478K variant (rabbit IgG1 Fc-tagged)

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SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain L452R, T478K variant (rabbit IgG1 Fc-tagged) Basic information
Product Name:SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain L452R, T478K variant (rabbit IgG1 Fc-tagged)
Synonyms:SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain L452R, T478K variant (rabbit IgG1 Fc-tagged)
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SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain L452R, T478K variant (rabbit IgG1 Fc-tagged) Structure
SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain L452R, T478K variant (rabbit IgG1 Fc-tagged) Chemical Properties
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SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain L452R, T478K variant (rabbit IgG1 Fc-tagged) Usage And Synthesis
DescriptionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of COVID-19.1,2,3,4,5 The SARS-CoV-2 spike glycoprotein, also known as the surface glycoprotein, is located on the outer envelope of the virion.1 It is composed of an S1 and S2 subunit divided by a furin S-cleavage site not found in other SARS-CoVs.6,7 The S1 subunit contains the receptor-binding domain (RBD), which binds to the carboxypeptidase angiotensin-converting enzyme 2 (ACE2), and the S1 and S2 subunits are cleaved by the protease TMPRSS2 to facilitate viral fusion with the host cell membrane.8,9,10 In this way, ACE2 acts as the functional receptor for SARS-CoV-2. The SARS-CoV-2 variant of concern (VOC) B.1.617.2, also known as the delta variant, that was originally identified in India, contains the L452R and T478K substitutions.11 The leucine-to-arginine substitution at position 452 (L452R) increases SARS-CoV-2 affinity for human ACE2, decreases serum neutralization and binding with monoclonal antibodies, and promotes viral infectivity and replication.12,13 The threonine-to-lysine substitution at position 478 (T478K) also induces structural changes in the receptor- and antibody-binding interfaces.14 Cayman's SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain L452R, T478K variant (rabbit IgG1 Fc-tagged) protein can be used for ELISA and surface plasmon resonance (SPR) applications.WARNING This product is not for human or veterinary use.
SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain L452R, T478K variant (rabbit IgG1 Fc-tagged) Preparation Products And Raw materials
Tag:SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain L452R, T478K variant (rabbit IgG1 Fc-tagged) Related Product Information
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