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| | Ste-MPKKKPTPIQLNP-NH2 Basic information |
| Product Name: | Ste-MPKKKPTPIQLNP-NH2 | | Synonyms: | STEARYL-MEK-1 DERIVED PEPTIDE INHIBITOR 1, AMIDE;STE-MEK1(13);STE-MET-PRO-LYS-LYS-LYS-PRO-THR-PRO-ILE-GLN-LEU-ASN-PRO-NH2;ERK ACTIVATION INHIBITOR PEPTIDE I, CELL-PERMEABLE;L-Prolinamide, N-(1-oxooctadecyl)-L-methionyl-L-prolyl-L-lysyl-L-lysyl-L-lysyl-L-prolyl-L-threonyl-L-prolyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-asparaginyl-;Ste-MPKKKPTPIQLNP-NH2 | | CAS: | 566872-15-9 | | MF: | C86H153N19O17S | | MW: | 1757.32 | | EINECS: | | | Product Categories: | peptide | | Mol File: | Mol File |  |
| | Ste-MPKKKPTPIQLNP-NH2 Chemical Properties |
| Boiling point | 1814.130±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.196±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | -20°C | | solubility | water: 1 mg/mL || DMSO: 5 mg/mL | | form | lyophilized solid | | pka | 13.329±0.46(predicted) | | color | white | | Water Solubility | water: 1mg/mL
DMSO: 5mg/mL | | Sequence | {Ste}-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH2 |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | Ste-MPKKKPTPIQLNP-NH2 Usage And Synthesis |
| Uses | STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH ) is a cell permeable ERK1/2 inhibitor (IC50: 13-30 μM). STE-MEK1(13) inhibits ERK1/2 phosphorylation[1][2]. | | Biological Activity | Cell permeable: yes', 'Primary Target
MEK', 'Product does not compete with ATP.', 'Reversible: yes | | References | [1] Li G, et al. A novel cellular survival factor--the B2 subunit of vacuolar H+-ATPase inhibits apoptosis. Cell Death Differ. 2006 Dec;13(12):2109-17. DOI:10.1038/sj.cdd.4401970
[2] Whiteman M, et al. Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells. Osteoarthritis Cartilage. 2006 May;14(5):460-70. DOI:10.1016/j.joca.2005.11.002 |
| | Ste-MPKKKPTPIQLNP-NH2 Preparation Products And Raw materials |
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