| Company Name: |
Cool Pharm, Ltd |
| Tel: |
021-60455363 18019463053 |
| Email: |
sales@coolpharm.com |
|
| | 3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxylic acid ethyl ester Basic information |
| Product Name: | 3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxylic acid ethyl ester | | Synonyms: | 4-Piperidinecarboxylic acid, 1-(4-pyridinyl)-, ethyl ester;Ethyl 1-(pyridin-4-yl)piperidine-4-carboxylate;1-pyridin-4-yl-4-piperidinecarboxylic acid ethyl ester;Ethyl 1-(4-pyridinyl)-4-piperidinecarboxylate;Ethyl 1-(4-pyridinyl)piperidine-4-carboxylate;3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxylic acid ethyl ester | | CAS: | 121912-29-6 | | MF: | C13H18N2O2 | | MW: | 234.29 | | EINECS: | | | Product Categories: | | | Mol File: | 121912-29-6.mol | ![3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxylic acid ethyl ester Structure](CAS/GIF/121912-29-6.gif) |
| | 3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxylic acid ethyl ester Chemical Properties |
| Boiling point | 356.4±32.0 °C(Predicted) | | density | 1.120±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 10.88±0.10(Predicted) |
| | 3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxylic acid ethyl ester Usage And Synthesis |
| Synthesis | Example 2 Difluorotriacetate of [1-(pyridin-4-yl)piperidin-4-yl]methyl 2-[amino(imino)methyl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid; Step 1 Synthesis of ethyl 1-(pyridin-4-yl)piperidin-4- carboxylate; To a 1-(pyridin-4-yl)piperidin-4-carboxylic acid (20.0 g, 97.0 mmol) ethanol (480 mL) suspension of thionyl chloride (7.1 mL, 97.0 mmol) was added dropwise and the mixture was stirred at 50°C overnight. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the resulting residue was diluted with dichloromethane, washed sequentially with 1N aqueous sodium hydroxide and saturated aqueous ammonium chloride, the organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford ethyl 1-(pyridin-4-yl)piperidine-4-carboxylate, which did not require further purification. Yield: 21.0 g (89.7 mmol, 93%). MS (ESI, m/z): 235 [M + H]+. 1H-NMR (CDCl3) δ: 1.26 (t, 3H), 1.72-1.86 (m, 2H), 1.97-2.05 (m, 2H), 2.49-2.58 (m, 1H), 2.93-3.02 (m , 2H), 3.82-3.02 (m, 2H). , 2H), 3.82 (dt, 2H), 4.16 (q, 2H), 6.66 (dd, 2H), 8.25 (dd, 2H). | | References | [1] Patent: EP2311810, 2011, A1. Location in patent: Page/Page column 21
[2] Tetrahedron, 1988, vol. 44, # 23, p. 7095 - 7108 |
| | 3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxylic acid ethyl ester Preparation Products And Raw materials |
|