丁基硫
| 中文名称 | 丁基硫 |
|---|---|
| 中文同义词 | DL-(3-氨基-4-羧丙基)-(S,R)-丁基硫氧亚胺;DL-丁硫氨酸(S,R)-亚砜亚胺;DL-丁硫氨酸-(S,R)-亚砜胺;DL-丁硫氨酸亚砜;DL-丁硫氨酸-(S,R)-亚砜亚胺;丁基硫;丁硫胺酸亚砜胺(BSO);DL-丁硫氨酸-S,R-磺基 |
| 英文名称 | DL-BUTHIONINE-[S,R]-SULFOXIMINE |
| 英文同义词 | DL-BUTHIONINE (R,S)-SULFOXIMINE;DL-BUTHIONINE-[S,R]-SULFOXIMINE;DL-BUTHIONINE (S,R)-SULPHOXIME;DL-BUTHIONINE-SULFOXIMINE;2-amino-4-(s-butylsulfonimidoyl)-butanoicaci;2-amino-4-(s-butylsulfonimidoyl)butanoicacid;buthioninesulfoxamine;buthioninesulphoximine |
| CAS号 | 5072-26-4 |
| 分子式 | C8H18N2O3S |
| 分子量 | 222.31 |
| EINECS号 | 628-045-7 |
| 相关类别 | Glutathione S-Transferase Agents;Sulfur & Selenium Compounds;D to;Drug and Xenobiotic Metabolism;Enzyme Inhibitors by Enzyme;Fusarinine -C OrnithinesteraseMulti-Drug Resistance and Drug Metabolism;Substrates, Inducers, Inhibitors |
| Mol文件 | 5072-26-4.mol |
| 结构式 |  |
丁基硫 性质
| 熔点 | 215 °C (dec.)(lit.) |
|---|---|
| 沸点 | 382.3±52.0 °C(Predicted) |
| 密度 | 1.29±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | H2O：50 mg/mL，澄清，无色 |
| 形态 | 蓬松粉末 |
| 颜色 | 白色 |
| 生物来源 | synthetic (organic) |
| 水溶解性 | water: 50mg/mL, clear to very slightly hazy, colorless to yellow |
| Merck | 13,1520 |
| BRN | 2367136 |
| InChI | 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12) |
| InChIKey | KJQFBVYMGADDTQ-UHFFFAOYSA-N |
| SMILES | CCCCS(=N)(=O)CCC(N)C(O)=O |
| CAS 数据库 | 5072-26-4(CAS DataBase Reference) |
DL-Buthionine-Sulfoximine (BSO, DL-Buthionine-(S,R)-sulfoximine)是一种 glutathione (GSH) 合成的抑制剂。
| Target | Value |
|
GSH
() |
Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine.
Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors.
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