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| | 4-chloroquinoline-7-carboxylic acid Basic information |
| Product Name: | 4-chloroquinoline-7-carboxylic acid | | Synonyms: | 4-chloroquinoline-7-carboxylic acid;4-chloro-7-quinolinecarboxylic acid;3-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino)benzonitrile;7-Quinolinecarboxylic acid, 4-chloro-;4-chloroquinoline-7-carboxylic acid - [C86828];2,2'-Biquinoline-4,4'-diyl bis(phosphine) iridium(I) complex | | CAS: | 49713-58-8 | | MF: | C10H6ClNO2 | | MW: | 207.61 | | EINECS: | 200-589-5 | | Product Categories: | CHIRAL CHEMICALS | | Mol File: | 49713-58-8.mol |  |
| | 4-chloroquinoline-7-carboxylic acid Chemical Properties |
| Boiling point | 364.2±27.0 °C(Predicted) | | density | 1.469±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 3.70±0.27(Predicted) | | Appearance | White to off-white Solid |
| | 4-chloroquinoline-7-carboxylic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 4-chloroquinoline-7-carboxylic acid from 4-chloro-7-trifluoromethylquinoline: 10.0 g (43.2 mmol) of 4-chloro-7-trifluoromethylquinoline was dissolved in 200 mL of concentrated hydrochloric acid. The reaction was heated in a microwave reactor with radiation at 550 W power for 2 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ice water and the pH was adjusted to 3-4 with sodium hydroxide solution.The precipitated product was collected by diafiltration, washed several times with deionized water and subsequently dried. Finally 8.9 g of 4-chloroquinoline-7-carboxylic acid was obtained in 99% yield of the theoretical value. Thin layer chromatography (TLC) analysis showed an Rf value of 0.45 (silica gel plate, unfolding agent was toluene/ethanol = 4:1). The molecular formula of the product was C10H6ClNO2 (molecular weight 207.62), and the mass spectrometry analysis showed that the molecular ion peak (M+H)+ was 208/210 (chlorine isotope peak). | | References | [1] Patent: WO2004/58743, 2004, A1. Location in patent: Page/Page column 116-117
[2] Patent: WO2004/80970, 2004, A1. Location in patent: Page 34; 35
[3] Patent: WO2016/118565, 2016, A1. Location in patent: Paragraph 00320
[4] Patent: US2004/102450, 2004, A1. Location in patent: Page/Page column 72
[5] Patent: US5773449, 1998, A |
| | 4-chloroquinoline-7-carboxylic acid Preparation Products And Raw materials |
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