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| | (1S,4R)-2-Aza-bicyclo[2.2.1]hept-5-en-3-one Basic information |
| | (1S,4R)-2-Aza-bicyclo[2.2.1]hept-5-en-3-one Chemical Properties |
| Melting point | 94-97 °C(lit.) | | Boiling point | 319.3±0.0 °C(Predicted) | | density | 1.198±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | powder | | pka | 15.48±0.20(Predicted) | | color | Off-white | | Optical Rotation | [α]20/D +565°, c = 1 in chloroform | | InChI | InChI=1S/C6H7NO/c8-6-4-1-2-5(3-4)7-6/h1-2,4-5H,3H2,(H,7,8)/t4-,5+/m0/s1 | | InChIKey | DDUFYKNOXPZZIW-CRCLSJGQSA-N | | SMILES | [C@]12([H])C[C@]([H])(C=C1)C(=O)N2 | | CAS DataBase Reference | 130931-83-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 2914290090 |
| | (1S,4R)-2-Aza-bicyclo[2.2.1]hept-5-en-3-one Usage And Synthesis |
| Chemical Properties | OFF-WHITE TO BEIGE CRYSTALLINE POWDER | | Uses | This lactam and its antipode are precursors to the enantiomers of the carbocyclic nucleoside carbovir. It has been demonstrated that (-)-carbovir is a potent inhibitor of HIV-1 and based on clinical trials it could become an alternative to AZT. AZT is a trademark of The Wellcome Foundation Ltd. | | Synthesis | GENERAL METHOD: Unreacted N-hydroxymethyl-γ-lactams (1S,4R)-1 and (1R,4S)-2 (20 mg, 0.14 mmol) were dissolved in methanol (2 mL). Subsequently, ammonium hydroxide (2 mL) was added and the reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator and the residue was purified by silica gel column chromatography, using ethyl acetate as eluent, to afford white crystals of (1S,4R)-3 [15 mg, 95%; [α]D25 = +545 (c 0.3, CHCl3), ee = 99%; literature value 13: [α]D25 = +549 (c 0.26, CHCl3), ee > 99%; melting point 95-98°C (recrystallized from i-Pr2O), literature value 13: 97-100°C] or (1R,4S)-4 [15 mg, 93%; [α]D25 = +125.5 (c 0.55, CHCl3), ee = 96%; literature value 13: [α]D25 = +158 (c 0.45, CHCl3), ee > 99%; melting point 78-81°C (recrystallized from i-Pr2O), literature value 13: 78-81°C]. （1H NMR (400 MHz, CDCl3, 25 °C, TMS) data for (1S,4R)-3: δ = 2.18-2.43 (m, 2H, CH2); 3.18-3.24 (m, 1H, CHCO); 4.30-4.37 (m, 1H, CHNH); 6.05 (br s, 1H, NH); 6.63-6.82 ( m, 2H, CH=CH). Elemental analysis: calculated values (C6H7NO): C, 66.04; H, 6.47; N, 12.84; measured values: C, 66.12; H, 6.38; N, 12.82. 1H NMR (400 MHz, CDCl3, 25 °C, TMS) data for (1R,4S)-4: δ = 1.33-1.97 (m, 6H, 3 × CH2) ; 2.76-2.85 (m, 1H, CHCO); 3.04 (br s, 1H, NH); 3.95-4.08 (m, 1H, CHNH). Elemental analysis: calculated values (C6H9NO): C, 64.84; H, 8.16; N, 12.60; measured values: C, 64.81; H, 8.13; N, 12.68. | | References | [1] Tetrahedron Asymmetry, 2016, vol. 27, # 16, p. 729 - 731
[2] Tetrahedron Asymmetry, 1996, vol. 7, # 8, p. 2381 - 2386
[3] Tetrahedron: Asymmetry, 1994, vol. 5, # 7, p. 1155 - 1156 |
| | (1S,4R)-2-Aza-bicyclo[2.2.1]hept-5-en-3-one Preparation Products And Raw materials |
| Raw materials | 2-Azabicyclo[2.2.1]hept-5-en-3-one-->2-Azabicyclo[2.2.1]hept-5-en-3-one, 2-(hydroxymethyl)-, (1S,4R)--->Ammonium hydroxide-->Methanol | | Preparation Products | ((1R,4S)-2-Azabicyclo[2.2.1]hept-5-en-3-one-->Cyclopentanecarboxylic acid, 3-amino-, methyl ester, (1S,3R)- (9CI)-->2-Azabicyclo[2.2.1]heptan-3-one-->2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 3-oxo-, 1,1-dimethylethyl ester, (1S)- |
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