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| | TYR-D-ALA-GLY-PHE-MET Basic information |
| Product Name: | TYR-D-ALA-GLY-PHE-MET | | Synonyms: | a,a-D-Trehaloseanhydrous;enkephalin-Met, Ala(2)-;L-TYR-D-ALA-GLY-PHE-MET;L-TYR-D-ALA-GLY-PHE-MET-OL CH3COOH;H-TYR-D-ALA-GLY-PHE-MET-OH;ENKEPHALIN, MET- (D-ALA2);(D-ALA2) MET-ENKEPHALIN;(D-ALA2-OL)-MET ENKEPHALIN | | CAS: | 61370-87-4 | | MF: | C28H37N5O7S | | MW: | 587.69 | | EINECS: | | | Product Categories: | | | Mol File: | 61370-87-4.mol |  |
| | TYR-D-ALA-GLY-PHE-MET Chemical Properties |
| | TYR-D-ALA-GLY-PHE-MET Usage And Synthesis |
| Description | Enkephalin-met, ala(2)- is a synthetic analog of methionine enkephalin. | | Uses | [D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2]. | | in vivo | [D-Ala2]-Met-Enkephalin (0.01-1μg; ICV; once) inhibits suckling-induced oxytocin (OT) release in lactating mice[1]. | Animal Model: | Lactating rats[1] | | Dosage: | 0.01, 0.1 and 1 μg | | Administration: | Intracerebroventrical injection | | Result: | Inhibited ACh-induced and suckling-induced OT release. |
| | References | [1] Haldar J, et, al. Morphine, β-endorphin and [D-Ala2] Met-enkephalin inhibit oxytocin release by acetylcholine and suckling. 1982 Jul–Aug;3(4):663-8.
[2] Godoy AM, et, al. Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus. 1995 Mar;50(3):445-51. |
| | TYR-D-ALA-GLY-PHE-MET Preparation Products And Raw materials |
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