N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine

Request For Quotation
N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine Suppliers list
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Company Name: Hubei wei shi reagent group ltd., company  
Tel: 027-59102966 18717199209
Email: 2853877583@qq.com
Company Name: Bide Pharmatech Ltd.  
Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310 15002144251
Email: marketing@tsbiochem.com
Company Name: Suzhou Zhixin Biotechnology Co., Ltd.  
Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine Basic information
Product Name:N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine
Synonyms:N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine;N-[3,5-bis(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide;1,2-Benzisothiazol-3-amine, N-[3,5-bis(trifluoromethyl)phenyl]-, 1,1-dioxide;M1002, 10 mM in DMSO;3-((3,5-Bis(trifluoromethyl)phenyl)amino)benzo[d]isothiazole 1,1-dioxide
CAS:823830-85-9
MF:C15H8F6N2O2S
MW:394.29
EINECS:
Product Categories:
Mol File:823830-85-9.mol
N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine Structure
N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine Chemical Properties
Boiling point 414.6±55.0 °C(Predicted)
density 1.60±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka-2.13±0.20(Predicted)
color White to off-white
Safety Information
MSDS Information
N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine Usage And Synthesis
UsesM1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors[1].
Biological ActivityM1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors[1]. M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy[1].M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors[1].
References[1]. Dalei Wu, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15(4):367-376.
N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine Preparation Products And Raw materials
Tag:N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine(823830-85-9) Related Product Information
2-[(diethylamino)methyl]-4-[(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]phenol 3-(1,1-Dioxo-1H-1lambda6-benzo[d]isothiazol-3-ylamino)-phenol N-ethyl-1,2-benzothiazol-3-amine 1,1-dioxide 4-[(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]-N-phenylbenzenesulfonamide 4-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-2-(piperidin-1-ylmethyl)phenol 1,1-dioxo-N-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine