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| | DL-1-Phenethylalcohol Basic information |
| Product Name: | DL-1-Phenethylalcohol | | Synonyms: | (1-Hydroxyethyl)benzene;α-MethylbenzeneMethanol;(±)-α-Methylbenzyl alcohol, (±)-1-Phenylethanol, Methyl phenyl carbinol, Styrallyl alcohol, Styrene alcohol;(±)-α-Methylbenzyl alcohol, Methyl phenyl carbinol, Styrallyl alcohol, Styrene alcohol;ALPHA-PHENYLALCOHOL;DL-sec-Phenethyl alcohol,98%;DL-sec-Phenethyl alcohol,97%;DL-sec-Phenethyl alcohol,99+% | | CAS: | 98-85-1 | | MF: | C8H10O | | MW: | 122.16 | | EINECS: | 202-707-1 | | Product Categories: | Alcohols;Building Blocks;C7 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds | | Mol File: | 98-85-1.mol |  |
| | DL-1-Phenethylalcohol Chemical Properties |
| Melting point | 19-20 °C(lit.) | | Boiling point | 204 °C745 mm Hg(lit.) | | density | 1.012 g/mL at 25 °C(lit.) | | vapor density | 4.21 (vs air) | | vapor pressure | 0.1 mm Hg ( 20 °C) | | refractive index | n20/D 1.527(lit.) | | FEMA | 2685 | ALPHA-METHYLBENZYL ALCOHOL | | Fp | 185 °F | | solubility | Chloroform (Sparingly), Ethyl Acetate, Methanol (Sparingly) | | pka | 14.43±0.20(Predicted) | | form | Liquid | | color | Clear colorless | | Odor | at 100.00 %. fresh sweet acetophenone gardenia hyacinth | | Odor Type | chemical | | biological source | synthetic | | Water Solubility | 29 g/L (20 ºC) | | JECFA Number | 799 | | BRN | 1905149 | | Dielectric constant | 7.6（90℃） | | Stability: | Stable. Combustible. Incompatible with strong acids, strong oxidizing agents. | | Major Application | flavors and fragrances | | Cosmetics Ingredients Functions | PERFUMING | | InChI | 1S/C8H10O/c1-7(9)8-5-3-2-4-6-8/h2-7,9H,1H3 | | InChIKey | WAPNOHKVXSQRPX-UHFFFAOYSA-N | | SMILES | CC(O)c1ccccc1 | | LogP | 1.636 at 25℃ | | CAS DataBase Reference | 98-85-1(CAS DataBase Reference) | | NIST Chemistry Reference | Benzenemethanol, «alpha»-methyl-(98-85-1) | | EPA Substance Registry System | .alpha.-Methylbenzenemethanol (98-85-1) |
| Hazard Codes | Xn | | Risk Statements | 22-38-41-36/37/38 | | Safety Statements | 26-39-37/39 | | RIDADR | UN 2937 6.1/PG 3 | | WGK Germany | 1 | | RTECS | DO9275000 | | TSCA | TSCA listed | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29400090 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2 | | Hazardous Substances Data | 98-85-1(Hazardous Substances Data) |
| | DL-1-Phenethylalcohol Usage And Synthesis |
| Chemical Properties | DL-1-Phenethylalcohol is a colorless liquid with a mild hyacinth–gardenia odor. It solidifies below room temperature, with a melting point of 20.7°C and a boiling point of 204°C. It is soluble in ethanol, propylene glycol, and most non-volatile oils, and readily dissolves in glycerin and mineral oil. Slightly soluble in water. | | Description | DL-1-Phenethylalcohol has been identified as a volatile component of food (e.g., in tea aroma and mushrooms). The alcohol is a colorless liquid with a dry, rose-like odor, slightly reminiscent of hawthorn. It can be prepared by catalytic hydrogenation of acetophenone. 1- Phenylethyl alcohol is used in small quantities in perfumery and in larger amounts for the production of its esters, which are more important as fragrance materials. | | Occurrence | Two optically active isomers exist; the commercial product is the racemic form. Reported found in cranberry,
grapes, chive, Scotch spearmint oil, cheeses, cognac, rum, white wine, cocoa, black tea, filbert, cloudberry, beans, mushroom and
endive. | | Uses | The Arthrobacter sp. is able to grow with (+ I-,(-)-1-phenylethanol or the racemic mixture as sole source of carbon. Growth is most rapid with the (-)-isomer, doubling time 12 h. Lipases show good activity and, in some cases, improved enantioselectivity when employed in pure ionic liquids for dynamic kinetic resolution of 1-phenylethanol by transesterification. | | Preparation | By oxidation of ethylbenzene or by reduction of acetophenone. | | Definition | ChEBI: 1-phenylethanol is an aromatic alcohol that is ethanol substituted by a phenyl group at position 1. It has a role as a mouse metabolite. | | Production Methods | 1-Phenylethanol is coproduced with propylene oxide by
reaction of a-peroxyethylbenzene (formed by the oxidation
of ethylbenzene) with propylene. It is used as a fragrance additive in cosmetics such as perfumes, creams,
and soaps and is an intermediate in styrene production.
1-Phenylethanol is also added to foods as a flavoring agent. Industrial exposure may occur from dermal contact and ingestion. | | Taste threshold values | Taste characteristics at 50 ppm: chemical, medicinal, with a balsamic vanilla woody nuance. | | Synthesis Reference(s) | Tetrahedron Letters, 36, p. 3861, 1995 DOI: 10.1016/0040-4039(95)00679-7 | | General Description | A colorless liquid. Insoluble in water and less dense than water. Contact may slightly irritate skin, eyes and mucous membranes. May be slightly toxic by ingestion, inhalation and skin absorption. Used to make other chemicals. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | Attacks plastics. [Handling Chemicals Safely, 1980. p. 236]. Acetyl bromide reacts violently with alcohols or water [Merck 11th ed. 1989]. Mixtures of alcohols with concentrated sulfuric acid and strong hydrogen peroxide can cause explosions. Example: An explosion will occur if dimethylbenzylcarbinol is added to 90% hydrogen peroxide then acidified with concentrated sulfuric acid. Mixtures of ethyl alcohol with concentrated hydrogen peroxide form powerful explosives. Mixtures of hydrogen peroxide and 1-phenyl-2-methyl propyl alcohol tend to explode if acidified with 70% sulfuric acid [Chem. Eng. News 45(43):73. 1967; J, Org. Chem. 28:1893. 1963]. Alkyl hypochlorites are violently explosive. They are readily obtained by reacting hypochlorous acid and alcohols either in aqueous solution or mixed aqueous-carbon tetrachloride solutions. Chlorine plus alcohols would similarly yield alkyl hypochlorites. They decompose in the cold and explode on exposure to sunlight or heat. Tertiary hypochlorites are less unstable than secondary or primary hypochlorites [NFPA 491 M. 1991]. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence [Wischmeyer 1969]. | | Health Hazard | Irritating to the skin, eyes, nose, throat, and upper respiratory tract. | | Fire Hazard | Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. | | Flammability and Explosibility | Not classified | | Safety Profile | Poison by ingestion and subcutaneous routes. Moderately toxic by skin contact. A skin and severe eye irritant. Questionable carcinogen. Combustible when exposed to heat or flame; can react with oxidming materials. To fight fire, use alcohol foam, foam, CO2, dry chemical | | Carcinogenicity | In an NTP study, both sexes of F344 rats were dosed by gavage with 0, 375, and 750 mg/kg
1-phenylethanol 5 days/week for 2 years. There was an
increased incidence of neoplastic kidney tumors in the
high-dose male rats but no evidence of carcinogenicity in
the female rats . In the same NTP study, both sexes of
B6C3F1 mice were dosed by oral gavage with 0, 375, and
750 mg/kg 1-phenylethanol 5 days/week for 2 years. There
was no evidence that 1-phenylethanol was carcinogenic to
mice in this study. | | Purification Methods | Purify the alcohol via its hydrogen phthalate. [See Houssa & Kenyon J Chem Soc 2260 1930.] Shake it with a solution of ferrous sulfate, and th |
| | DL-1-Phenethylalcohol Preparation Products And Raw materials |
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