LEUROSINE manufacturers
- LEUROSINE
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2020-01-10
- CAS:23360-92-1
- Min. Order: 1KG
- Purity: 98%; 99%
- Supply Ability: 500g;1kg； 25kg
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| | LEUROSINE Basic information |
| Product Name: | LEUROSINE | | Synonyms: | 4’-deoxy-3’,4’-epoxy-,(3’-alpha,4’-alpha)-vincaleukoblastin;4’-deoxy-3’,4’-epoxy-,(3’alpha,4’alpha)-vincaleukoblastin;amotin;LEUROSINE;Vincristine EP Impurity F;Vinorelbine EP Impurity E/Leurosine/4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester;Vincristine EP Impurity F (Leurosine);nsc-528004 | | CAS: | 23360-92-1 | | MF: | C46H56N4O9 | | MW: | 808.97 | | EINECS: | | | Product Categories: | | | Mol File: | 23360-92-1.mol |  |
| | LEUROSINE Chemical Properties |
| Melting point | 202-205℃ | | density | 1.39 | | pka | 11.36±0.60(Predicted) |
| RIDADR | 1544 | | HazardClass | 6.1(a) | | PackingGroup | II | | Hazardous Substances Data | 23360-92-1(Hazardous Substances Data) | | Toxicity | dog,LDLo,intraperitoneal,12mg/kg (12mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987. |
| | LEUROSINE Usage And Synthesis |
| Description | Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals
that are best purified by recrystallization from acetonitrile. It crystallizes with 8
moles of H20 and loses solvent when heated at In-5°C. It is also dextro
rotatory with [α]26D + n° (CHCI3)’ A crystalline SUlphate is known which has
m.p. 238-242°C (dec.) and [α]D - 8.3° (MeOH). The N(b)-oxide is identical
with pleurosine (q.v.). | | Uses | Antineoplastic. | | Uses | Vinleurosine is an antitumor compound derived from Vinca Rosea. | | Definition | ChEBI: Leurosine is a vinca alkaloid. | | References | Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)
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| | LEUROSINE Preparation Products And Raw materials |
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