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| | 1,2-Dimyristoyl-3-trimethylammonium-propane Basic information |
| Product Name: | 1,2-Dimyristoyl-3-trimethylammonium-propane | | Synonyms: | 14:0 TAP;N,N,N-Trimethyl-2,3-bis(tetradecanoyloxy)propan-1-aminium chloride;TAP (14:0);1,2-dimyristoyl-3-trimethylammonium-propane (chloride salt);1,2-Dimyristoyl-3-trimethylammoniumpropane (chloride);1,2-Dimyristoyl-3-trimethylammonium-propane | | CAS: | 197974-74-6 | | MF: | C34H68NO2+ | | MW: | 522.91 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 1,2-Dimyristoyl-3-trimethylammonium-propane Chemical Properties |
| storage temp. | -20°C | | solubility | Chloroform: 10 mg/ml | | form | powder | | InChIKey | WOSYUIOSAOFINL-UHFFFAOYSA-M | | SMILES | [H]C(C[N+](C)(C)C)(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O.[Cl-] |
| WGK Germany | WGK 3 | | Storage Class | 6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects | | Hazard Classifications | Acute Tox. 3 Inhalation
Acute Tox. 4 Oral
Carc. 2
Eye Irrit. 2
Repr. 2
Skin Irrit. 2
STOT RE 1 Oral
STOT SE 3 |
| | 1,2-Dimyristoyl-3-trimethylammonium-propane Usage And Synthesis |
| Description | TAP (14:0) A cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery. TAP has been proven to be efficient for in vitro and in vivo transfection applications, which makes it one of the most widely used cationic lipids for gene transfection applications. | | Uses | DMTAP is a cationic lipid that can be used for delivery of DNA, RNAi and drugs[1][2][3]. | | References | [1] Gurtovenko AA, et al. Cationic DMPC/DMTAP lipid bilayers: molecular dynamics study. Biophys J. 2004 Jun;86(6):3461-72. DOI:10.1529/biophysj.103.038760
[2] Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811. DOI:10.1586/17434440.2013.855471
[3] Lajunen T, et al. Topical drug delivery to retinal pigment epithelium with microfluidizer produced small liposomes. Eur J Pharm Sci. 2014 Oct 1;62:23-32. DOI:10.1016/j.ejps.2014.04.018
[4] MISTUNI GHOSH. Cationic lipid nanodisks as an siRNA delivery vehicle.[J]. Biochemistry and Cell Biology, 2014, 92 3: 200-205. DOI: 10.1139/bcb-2014-0027 |
| | 1,2-Dimyristoyl-3-trimethylammonium-propane Preparation Products And Raw materials |
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