| Company Name: |
Rhawn Reagent |
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400-400-1332688 18019345275 |
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huyue@rhawn.cn |
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| | 1-Acetyl-6-nitroindoline Basic information |
| Product Name: | 1-Acetyl-6-nitroindoline | | Synonyms: | 1-Acetyl-2,3-dihydro-6-nitro-1H-indole;1-Acetyl-6-Nitroindole;1-(6-Nitroindolin-1-yl)ethanone;Ethanone, 1-(2,3-dihydro-6-nitro-1H-indol-1-yl)-;1-(6-nitro-1-indolinyl)ethanone;1H-Indole, 1-acetyl-2,3-dihydro-6-nitro-;Indoline, 1-acetyl-6-nitro-;1-(6-Nitroindolin-1-yl) | | CAS: | 22949-08-2 | | MF: | C10H10N2O3 | | MW: | 206.2 | | EINECS: | | | Product Categories: | | | Mol File: | 22949-08-2.mol |  |
| | 1-Acetyl-6-nitroindoline Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature |
| | 1-Acetyl-6-nitroindoline Usage And Synthesis |
| Synthesis | Step A: 6-Nitrodihydroindole (3.0 g, 18.3 mmol) was dissolved in tetrahydrofuran (THF, 45 mL) and triethylamine (Et3N, 3.4 mL, 24.4 mmol) at 0 °C. Acetyl chloride (1.5 mL, 21 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 30 minutes. After completion of the reaction, the mixture was partitioned between ethyl acetate (EtOAc) and aqueous hydrochloric acid (HCl aq.). The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 1-acetyl-6-nitrodihydroindole (3.8 g, 100% yield) as a yellow solid. | | References | [1] Patent: WO2006/19831, 2006, A1. Location in patent: Page/Page column 447
[2] Zhurnal Obshchei Khimii, 1959, vol. 29, p. 2541,2550; engl. Ausg. S. 2504, 2511
[3] Heterocycles, 1998, vol. 48, # 12, p. 2481 - 2484 |
| | 1-Acetyl-6-nitroindoline Preparation Products And Raw materials |
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