9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]-

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9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]- manufacturers

  • DUB-IN-1
  • DUB-IN-1 pictures
  • $35.00
  • 2026-07-27
  • CAS:924296-18-4
  • Purity: 98.69%
  • Supply Ability: 10g
  • DUB-IN-1
  • DUB-IN-1 pictures
  • $35.00
  • 2026-07-27
  • CAS:924296-18-4
  • Purity: 98.69%
  • Supply Ability: 10g
9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]- Basic information
Product Name:9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]-
Synonyms:9-[(Phenylmethoxy)imino]-9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile;DUBs inhibitor 1;DUBs-IN-1;9-Benzyloxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile;USP8-IN-22d;DUB-IN-1;Deubiquitinase,DUBs,Inhibitor,DUBIN1,inhibit,DUB IN 1;DUB-IN-1, 10 mM in DMSO
CAS:924296-18-4
MF:C20H11N5O
MW:337.33
EINECS:
Product Categories:
Mol File:924296-18-4.mol
9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]- Structure
9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]- Chemical Properties
Boiling point 632.213±65.00 °C(Press: 760.00 Torr)(predicted)
density 1.325±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (296.45 mM; Need ultrasonic)
form Powder
pka-10.161±0.20(predicted)
color Light yellow to yellow
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]- Usage And Synthesis
UsesDUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8[1].
Biological ActivityPotent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor.

DUB-IN-1 is a potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor (IC50 = 850 nM/USP8, >100 μM/USP7). DUB-IN-1 inhibits the proliferation (200-800 nM for 24 or 48h; LN229, U87MG, and T98G cells), invasion (500-800 nM for 48 or 96h; LN229 and T98G cells), and stemness (500-800 nM for 7 or 14 days; LN229 and T98G cells) in GBM cultures.
References[1] Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8. DOI:10.1002/cmdc.200900409
9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]- Preparation Products And Raw materials
Tag:9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]-(924296-18-4) Related Product Information
DUBs-IN-2 Tos-Arg-OMe HCl PI-1840 9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(2-propen-1-yloxy)imino]- proTAME UCHL1 Protein, Rat (His)