| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:(S)-Bromoenol lactone-d7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:(S)-Bromoenol lactone-d7
|
| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:(S)-Bromoenol lactone-d7
|
|
| | (S)-Bromoenol lactone-d7 Basic information |
| | (S)-Bromoenol lactone-d7 Chemical Properties |
| solubility | DMF: 50 mg/ml
DMSO: 25 mg/ml
Ethanol: 5 mg/mlPBS (pH 7.2): 0.05 mg/ml |
| | (S)-Bromoenol lactone-d7 Usage And Synthesis |
| Description | (S)-Bromoenol lactone-d7 ((S)-BEL-d7) is intended for use as an internal standard for the quantification of (S)-BEL by GC- or LC-MS. The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.1 The calcium-independent phospholipase A2 (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of iPLA2β that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM.2 (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ.WARNING This product is not for human or veterinary use. | | References | [1] SCHEUER W. Phospholipase A2–regulation and inhibition.[J]. Klinische Wochenschrift, 1989, 67 3: 153-159. DOI: 10.1007/bf01711343
[2] C. M. JENKINS. Identification of Calcium-independent Phospholipase A2 (iPLA2) β, and Not iPLA2γ, as the Mediator of Arginine Vasopressin-induced Arachidonic Acid Release in A-10 Smooth Muscle Cells[J]. The Journal of Biological Chemistry, 2002, 26 1: 32807-32814. DOI: 10.1074/jbc.m202568200 |
| | (S)-Bromoenol lactone-d7 Preparation Products And Raw materials |
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