| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
| Products Intro: |
Product Name:Bromoenol lactone-d7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:Bromoenol lactone-d7
|
| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:Bromoenol lactone-d7
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Bromoenol lactone-d7
Package:>=99% deuterated forMs (d1-d7) Remarks:9000528
|
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| | Bromoenol lactone-d7 Basic information |
| | Bromoenol lactone-d7 Chemical Properties |
| solubility | DMF: 50 mg/ml
DMSO: 25 mg/ml
Ethanol: 5 mg/mlPBS (pH 7.2): <50 µg/ml |
| | Bromoenol lactone-d7 Usage And Synthesis |
| Description | Bromoenol lactone-d7 (BEL-d7) contains seven deuterium atoms at the 2, 3, 4, 5, 6, 7, and 8 positions. It is intended for use as an internal standard for the quantification of BEL by GC- or LC-MS. BEL is a selective, potent, irreversible, mechanism-based inhibitor of phospholipase A2 (iPLA2) with a Ki value of 180 nM.1 It also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin (Ki = 636 nM).2,3WARNING This product is not for human or veterinary use. | | References | [1] S L HAZEN. Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2.[J]. The Journal of Biological Chemistry, 1991, 266 11: 7227-7232.
[2] E J ACKERMANN E A D K Conde Frieboes. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones.[J]. The Journal of Biological Chemistry, 1995, 270 1: 445-450. DOI: 10.1074/jbc.270.1.445
[3] J BALSINDE. Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1995, 92 18: 8527-8531. DOI: 10.1073/pnas.92.18.8527 |
| | Bromoenol lactone-d7 Preparation Products And Raw materials |
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