CAY10618
| 中文名称 | CAY10618 |
|---|---|
| 中文同义词 | 化合物 T15412;化合物 GPP78 |
| 英文名称 | CAY10618 |
| 英文同义词 | CAY10618;1H-1,2,3-Triazole-1-octanaMide, N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-;GPP 78;CAY10618 Exclusive;N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide;GPP78,GPP-78 |
| CAS号 | 1202580-59-3 |
| 分子式 | C27H29N5O |
| 分子量 | 439.55 |
| EINECS号 | |
| 相关类别 | 对照品;标准品 |
| Mol文件 | 1202580-59-3.mol |
| 结构式 |  |
CAY10618 性质
| 密度 | 1.15±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：10 mg/ml； DMSO：10 mg/ml； DMSO:PBS(pH 7.2)(1:3)：0.25 mg/ml；乙醇：10 mg/ml |
| 酸度系数(pKa) | 14.80±0.70(Predicted) |
| 形态 | 液体 |
| 颜色 | 无色至浅黄 |
Nampt;
Autophagy
GPP78 (Compound 8; 10 nM; 24-40 hours; SH-SY5Y cells) treatment with cells, punctate staining of LC3-II and the formation of autophagolysosomes are observable. LC3-II is membrane-bound and is present in autophagosomes.
GPP78 (Compound 8) inhibits the growth of most cell lines tested, with nanomolar potency (GI
50
) in cell lines derived from leukemia, lung, CNS, colon, melanoma, ovarian, renal, and prostate cancers. GPP78 appears truly cytotoxic in melanoma cell lines, while in the others it is mainly cytostatic.
Western Blot Analysis
| Cell Line: | SH-SY5Y cells |
| Concentration: | 10 nM |
| Incubation Time: | 24 hours, 40 hours |
| Result: | Punctate staining of LC3-II and the formation of autophagolysosomes were observable. |
GPP78 (10 mg/kg; intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days; male adult CD1 mice) treatment reduces the severity of spinal cord trauma in SCI mice.
| Animal Model: | Male adult CD1 mice (25-30 g) with spinal cord injury (SCI) |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days |
| Result: | Significantly reduced the demyelination associated with SCI. And significantly ameliorated the functional deficits induced by SCI. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-14374 | CAY10618 GPP78 | 1202580-59-3 | 1 mg (11.38 mM * 200 μL in Methanol) | 1150元 |
| 2026/06/05 | HY-14374 | CAY10618 GPP78 | 1202580-59-3 | 5mg(11.38mM * 1mL in Methanol) | 3500元 |