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| | PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt) Basic information |
| | PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt) Chemical Properties |
| solubility | DMSO: Slightly soluble:0.1-1 mg/mL
Ethanol: Slightly soluble:0.1-1 mg/mLPBS (pH 7.2): Sparingly soluble: 1-10 mg/mL
Water: Soluble |
| | PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt) Usage And Synthesis |
| Description | The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-(4,5)-P2 (1,2-dihexanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C6:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The natural compound is the product of PtdIns-4-phosphate 5-kinase acting on PtdIns-(4)-P1. Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.WARNING This product is not for human or veterinary use. | | References | [1] EXTON J H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins.[J]. Annual review of pharmacology and toxicology, 1996, 36: 481-509. DOI: 10.1146/annurev.pa.36.040196.002405
[2] MAJERUS P W. Inositol phosphate biochemistry.[J]. Annual review of biochemistry, 1992, 61: 225-250. DOI: 10.1146/annurev.bi.61.070192.001301 |
| | PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt) Preparation Products And Raw materials |
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