- AR 231453
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- $30.00
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2026-07-13
- CAS:733750-99-7
- Purity: 99.45%
- Supply Ability: 10g
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| | AR 231453 Basic information |
| Product Name: | AR 231453 | | Synonyms: | AR 231453;(2-FLUORO-4-METHANESULFONYL-PHENYL)-(6-[4-(3-ISOPROPYL-[1,2,4]OXADIAZOL-5-YL)-PIPERIDIN-1-YL]-5-NITRO-PYRIMIDIN-4-YL)-AMINE;N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-ni;N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5;CS-2809;AR231453; AR-231453;N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-amine;4-Pyrimidinamine, N-[2-fluoro-4-(methylsulfonyl)phenyl]-6-[4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-5-nitro- | | CAS: | 733750-99-7 | | MF: | C21H24FN7O5S | | MW: | 505.52 | | EINECS: | | | Product Categories: | Cannabinoids.;API | | Mol File: | 733750-99-7.mol |  |
| | AR 231453 Chemical Properties |
| Melting point | 174-176℃ | | Boiling point | 703.9±70.0 °C(Predicted) | | density | 1.421±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 25 mg/ml; DMSO: 3 mg/ml; Ethanol: insol; PBS (pH 7.2): insol | | pka | 3.24±0.10(Predicted) | | form | Yellow solid. | | color | Light yellow to yellow | | InChIKey | DGBKNTVAKIFYNU-UHFFFAOYSA-N | | SMILES | CC(C)C1=NOC(C(CC2)CCN2C(N=CN=C3NC4=CC=C(C=C4F)S(=O)(C)=O)=C3[N+]([O-])=O)=N1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | AR 231453 Usage And Synthesis |
| Uses | AR 231453 is a potent, specific and orally available GPR119 agonist. AR 231453 can stimulate β-cell replication and improve islet graft function s[1][2]. | | Biological Activity | AR231453 is a 5-nitropyrimidine derivative th at acts as a highly potent and selective GPR119 agonist (EC50/GPR119 species = 0.4 nM/monkey, 1.6 nM/dog, 4.7 nM/hamster, 3.5 nM/human, 12 nM/mouse, 4 nM/r at in cell-based assays), exhibiting no off-target activity toward 216 receptors, enzymes, and orphan GPCRs. AR231453 improves glucose tolerance in mice (3 mg/kg i.p. or 20 mg/kg, p.o.) and rats (3 mg/kg i.p.), while no in vivo efficacy is observed among GPR119-deficient mice. | | in vivo | AR231453 (20 mg/kg, orally) markedly improves oral glucose tolerance in a dose-dependent fashion, with efficacy similar to maximally effective doses of the sulfonylurea glyburide[1].
| Animal Model: | Mice[1]. | | Dosage: | 20 mg/kg. | | Administration: | Orally, once. | | Result: | Improved glucose tolerance in mice. |
| | References | [1] Chu ZL, et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9. DOI:10.1210/en.2006-1608
[2] J Gao, et al. Stimulating β-cell replication and improving islet graft function by AR231453, A GPR119 agonist. Transplant Proc. 2011 Nov;43(9):3217-20. DOI:10.1016/j.transproceed.2011.10.021 |
| | AR 231453 Preparation Products And Raw materials |
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