NS-1209 manufacturers
- NS 1209
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- $866.00
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2026-04-22
- CAS:205645-02-9
- Purity:
- Supply Ability: 10g
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| | NS-1209 Basic information |
| Product Name: | NS-1209 | | Synonyms: | 2-[[[5-[4-[(Dimethylamino)sulfonyl]phenyl]-1,2,6,7,8,9-hexahydro-8-methyl-2-oxo-3H-pyrrolo[3,2-h]isoquinolin-3-ylidene]amino]oxy]-4-hydroxybutanoic acid monosodium salt;NS-1209;SPD-502, NS-1209 | | CAS: | 205645-02-9 | | MF: | C24H27N4NaO7S | | MW: | 538.54855 | | EINECS: | | | Product Categories: | | | Mol File: | 205645-02-9.mol |  |
| | NS-1209 Chemical Properties |
| | NS-1209 Usage And Synthesis |
| Uses | SPD-502 sodium is a novel glutamate antagonist with potential neuroprotective properties, particularly in brain ischemia. It selectively targets the AMPA receptor, showing high affinity (IC50 = 0.043 μM) and competitive inhibition of AMPA-induced effects in rat cortical membranes and cultured mouse cortical neurons. In vivo, SPD-502 sodium effectively blocks AMPA-evoked spike activity in the hippocampus after intravenous administration, significantly increasing the seizure threshold in mice and demonstrating robust protection against ischemia-induced damage to hippocampal neurons in gerbils. These findings suggest SPD-502 sodium may be promising for treating neurodegenerative conditions associated with glutamate excitotoxicity[1]. | | References | [1] SPD-502: A Water-Soluble and In Vivo Long-Lasting Ampa Antagonist with Neuroprotective Activity |
| | NS-1209 Preparation Products And Raw materials |
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