| Company Name: |
Chiba Pharmaceutical Science and technology Co, Ltd.
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| Tel: |
0531-81313138 13066006660 |
| Email: |
chibapharm@foxmail.com |
| Products Intro: |
Product Name:4-broMo-5-chlorothiophene-2-carboxylic acid
CAS:60729-37-5
Purity:98% HPLC Package:5g;10g;25g;100g;250g;500g;1Kg
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| | 4-broMo-5-chlorothiophene-2-carboxylic acid Basic information |
| | 4-broMo-5-chlorothiophene-2-carboxylic acid Chemical Properties |
| Melting point | >200 °C | | Boiling point | 342.3±42.0 °C(Predicted) | | density | 2.019±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 3.31±0.10(Predicted) | | form | powder | | color | White |
| | 4-broMo-5-chlorothiophene-2-carboxylic acid Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 4-bromo-5-chlorothiophene-2-carboxylic acid from 2-chlorothiophene-5-carboxylic acid was as follows: a solution of bromine (634 μL, 12.3 mmol) in acetic acid (2.5 mL) was added slowly and dropwise to an acetic acid solution (25 mL) containing 5-chloro-2-thiophenecarboxylic acid (2 g, 12.3 mmol) and ferric chloride (399 mg, 2.50 mmol). mL) at 25 °C. Subsequently, the reaction mixture was heated to reflux during which bromine (634 μL, 12.3 mmol) and ferric chloride (399 mg, 2.50 mmol) were added in portions. After the reaction lasted for 7 days, the reaction solution was poured into ice water, the precipitate precipitated was filtered and washed with cold water to finally obtain 4-bromo-5-chlorothiophene-2-carboxylic acid (3 g, quantitative yield) as a yellow powder. The product was analyzed by liquid chromatography-mass spectrometry (LC-MS) and showed m/z 242 ([M+H]+). | | References | [1] Patent: WO2008/98104, 2008, A1. Location in patent: Page/Page column 81-82 |
| | 4-broMo-5-chlorothiophene-2-carboxylic acid Preparation Products And Raw materials |
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