- DANSYLCADAVERINE
-
- $1.00
-
2020-01-05
- CAS:10121-91-2
- Min. Order: 1KG
- Purity: 95-99%
- Supply Ability: 1ton
|
| | DANSYLCADAVERINE Basic information |
| Product Name: | DANSYLCADAVERINE | | Synonyms: | Monodansyl cadaverine, N-(5-Aminopentyl)-5-dimethylaminonaphthalene-1-sulfonamide, N-(Dimethylaminonaphthalenesulfonyl)-1,5-pentanediamine;N-(5-Aminopentyl)-5-(dimethylamino)-1-naphthalenesulfonamide;Einecs 233-326-9;Dansylcadaverine [N-(5-AMinopentyl)-5-diMethylaMinonaphthalen-1-sulfonaMide];N-(5-Amino-pentyl)-5-di-methyl-amino-naphtha-lene-1-sulfon-amide;N-(Dimethyl-amino-naphtha-lene-sulfonyl)-1;5-;DANSYLCADAVERINE [N-(5-AMINOPENTYL)-5-DIMETHYLAMINONAPHTHALEN-1-SULFONAMIDE];N-(5-AMINO-PENTYL)-5-DI-METHYL-AMINO-NAPHTHA-LENE-1-SULFON-AMIDE;N-(DIMETHYL-AMINO-NAPHTHA-LENE-SULFONYL)-1;5- | | CAS: | 10121-91-2 | | MF: | C17H25N3O2S | | MW: | 335.46 | | EINECS: | 233-326-9 | | Product Categories: | Naphthalene | | Mol File: | 10121-91-2.mol |  |
| | DANSYLCADAVERINE Chemical Properties |
| Melting point | 137-140 °C | | Boiling point | 505.5±60.0 °C(Predicted) | | density | 1.190±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Methanol: 10 mg/ml | | form | powder | | pka | 11.96±0.50(Predicted) | | color | Yellow to yellowish green | | Appearance | Solid Powder | | λmax | 335 nm | | BRN | 2951070 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month. | | Biological Applications | Measuring cardiac autophagic flux; treating cataract,fibrosis,Parkinson’s disease,peritoneal ovarian tumor dissemination,respiratory diseases,lung diseases,Huntington’s disease,spinobulbar atrophy,spinocerebellar ataxia,denta | | InChI | 1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3 | | InChIKey | MLEBFEHOJICQQS-UHFFFAOYSA-N | | SMILES | CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | F | 10-23 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | DANSYLCADAVERINE Usage And Synthesis |
| Description | Monodansylcadaverine (MDC) is a fluorescent marker for autophagic vacuoles. It is an autofluorescent substance incorporated into multilamellar bodies by both an ion trapping mechanism and interaction with membrane lipids, exhibiting a Stokes shift and increased relative fluorescence in hydrophobic environments. MDC selectively accumulates in PaTu 8902 subcellular fractions containing the lysosomal enzymes acid phosphatase and cathepsin D, but not those containing the rough and smooth endoplasmic reticulum markers TRAM and cytochrome P450, respectively. | | Uses | Fluorescent substrate for the assay of transamidating enzymes. | | Uses | Lysosomotropic fluorescent Probe | | Uses | Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells. | | Definition | ChEBI: Monodansylcadaverine is a sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine. It has a role as a fluorochrome, a protective agent and an EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor. It is a sulfonamide, an aminonaphthalene, a tertiary amino compound and a primary amino compound. It is functionally related to a cadaverine. | | References | [1] A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation
[2] QI JIANG. Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy.[J]. Journal of Urology, 2012, 188 4: 1361-1368. DOI:10.1016/j.juro.2012.06.004
[3] H T HAIGLER. Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.[J]. The Journal of Biological Chemistry, 1980, 255 4: 1239-1241.
[4] S N MURTHY. Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase.[J]. The Journal of Biological Chemistry, 1994, 269 36: 22907-22911.
[5] A NIEMANN H P E A Takatsuki. The lysosomotropic agent monodansylcadaverine also acts as a solvent polarity probe.[J]. Journal of Histochemistry & Cytochemistry, 2000, 48 2: 251-258. DOI: 10.1177/002215540004800210
[6] A BIEDERBICK H P E H F Kern. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles.[J]. European journal of cell biology, 1995, 66 1: 3-14. |
| | DANSYLCADAVERINE Preparation Products And Raw materials |
|