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| | 11-Hexadecenoic acid, 16-[[(ethylaMino)carbonyl]aMino]-, (11Z)- Basic information |
| | 11-Hexadecenoic acid, 16-[[(ethylaMino)carbonyl]aMino]-, (11Z)- Chemical Properties |
| Melting point | 83.1-83.3 °C | | Boiling point | 546.9±33.0 °C(Predicted) | | density | 0.986±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 3 mg/ml; Ethanol: 2 mg/ml | | pka | 4.78±0.10(Predicted) |
| | 11-Hexadecenoic acid, 16-[[(ethylaMino)carbonyl]aMino]-, (11Z)- Usage And Synthesis |
| Description | 17(R),18(S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EpETE), a natural cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid, is known to reduce the contraction rate of spontaneously beating heart cells and to protect neonatal rat cardiomyocytes against arrhythmias induced by β-adrenergic agonists (EC50 = ~ 1-2 nM).1 CAY10662 is a 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 < 1 nM) over its parent compound.1 At concentrations 1,000-fold higher than required for the effect on cardiomyocytes, 1-5 μM CAY10662 exerts weak dose-dependent soluble epoxide hydrolase inhibition.1 | | Uses | (Z)-16-(Ethylcarbamoylamino)hexadec-11-enoic acid (Compound 21) is a vasorelaxant (EC50=5.7 μM) that can be used in cardiovascular disease research[1]. | | References | 1. Falck, J.R., Wallukat, G., Puli, N., et al. 17(R),18(S)-Epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: Structure-activity relationships and stable analogues J. Med. Chem. 54(12),4109-4118(2011). |
| | 11-Hexadecenoic acid, 16-[[(ethylaMino)carbonyl]aMino]-, (11Z)- Preparation Products And Raw materials |
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