氧化苏木精
| 中文名称 | 氧化苏木精 |
|---|---|
| 中文同义词 | 海尔丹;苏木红;苏木因;天然黑1;氧化苏木红;氧化苏木精;氧化苏木素;3,4,6A,10-四羟基-6A,7-二氢茚并[2,1-C]苯并吡喃-9(6H)-酮 |
| 英文名称 | HEMATEIN |
| 英文同义词 | 3,4,6a,10-tetrahydroxy-6,7-dihydroindeno[2,1-c][1]benzopyran-9-one;TIMTEC-BB SBB006464;HEMATEIN FOR MICROSCOPY;LABOTEST-BB LT00441274;HYDROXYBRASILEIN;HEMATEIN;2-d)pyran-9(6h)-one,6a,7-dihydro-3,4,6a,10-tetrahydroxy-benz(b)indeno(;2-d]pyran-9(6h)-one,6a,7-dihydro-3,4,6a,10-tetrahydroxy-benz[b]indeno[ |
| CAS号 | 475-25-2 |
| 分子式 | C16H12O6 |
| 分子量 | 300.26 |
| EINECS号 | 207-492-8 |
| 相关类别 | 分析试剂-染料中间体;G-H-I;Stains and Dyes;Stains&Dyes, A to |
| Mol文件 | 475-25-2.mol |
| 结构式 |  |
氧化苏木精 性质
| 熔点 | 180 °C |
|---|---|
| 沸点 | 361.5°C (rough estimate) |
| 密度 | 1.2766 (rough estimate) |
| 折射率 | 1.4600 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 少许溶于甲醇 |
| 色指数 | 75290 |
| 酸度系数(pKa) | 8.02±0.40(Predicted) |
| 形态 | 结晶粉末 |
| 颜色 | 深棕色 |
| 水溶解性 | 0.6g/L(20 ºC) |
| Merck | 13,4651 |
| BRN | 93039 |
| LogP | 0.560 (est) |
| EPA化学物质信息 | Benz[b]indeno[1,2-d]pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy- (475-25-2) |
Hematein 是苏木精的氧化产物，可作为染料。Hematein 是一种变构酪蛋白激酶 II 抑制剂，IC50 为 0.74 μM。Hematein 抑制 Akt/PKB Ser129 磷酸化，Wnt/TCF 途径并增加肺癌细胞的凋亡。
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CKII 0.74 μM (IC 50 ) |
Akt
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Wnt
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Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation.
Cell Viability Assay
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 10-100 μM |
| Incubation Time: | 14 days |
| Result: | Inhibited cells growth. |
Apoptosis Analysis
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 50 and 100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced apoptosis in A427 lung cancer cells. |
Western Blot Analysis
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 50 and 100 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited CK2-specific Akt phosphorylation. |
Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts.
| Animal Model: | Female athymic BALB/c nude mice (6-week-old) |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injections; twice a week for 6 weeks |
| Result: | Inhibited tumor growth in A427 lung cancer cell xenografts. |
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